TRKA Protein (Fc Tag)
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- 抗原 See all TRKA (NTRK1) 蛋白
- TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This TRKA protein is labelled with Fc Tag.
- 原理
- Recombinant Mouse TrkA/NTRK1 Protein (Fc Tag)(Active)
- 序列
- Met1-Gly420
- 产品特性
- A DNA sequence encoding the mouse NTRK1 (Met1-Gly420) was expressed with the Fc region of human IgG1 at the C-terminus.
- 纯度
- > 90 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to inhibit NGF-induced proliferation of TF-1 human erythroleukemic cells.The ED50 for this effect is typically 0.02-0.08 μg/mL in the presence of 10 ng/mL of recombinant mouse NGF.
- Top Product
- Discover our top product NTRK1 蛋白
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Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 443-796) (Active) protein (His-GST)
NTRK1 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Active) protein (His tag)NTRK1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Active) protein (His tag)NTRK1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Active) protein (Fc Tag)NTRK1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 33-423) protein (His tag)Crystallography grade NTRK1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 440-796) protein (His tag)Crystallography grade NTRK1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 34-420) protein (His tag)Crystallography grade NTRK1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 442-799) protein (His tag)Crystallography grade NTRK1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 33-796) protein (rho-1D4 tag)Crystallography grade NTRK1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 34-799) protein (rho-1D4 tag)Crystallography grade NTRK1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
- 别名
- TrkA/NTRK1 (NTRK1 产品)
- 别名
- MTC Protein, TRK Protein, TRK1 Protein, TRKA Protein, Trk-A Protein, p140-TrkA Protein, CDHF12 Protein, CDHR16 Protein, HSCR1 Protein, MEN2A Protein, MEN2B Protein, MTC1 Protein, PTC Protein, RET-ELE1 Protein, RET51 Protein, Trk Protein, C80751 Protein, Tkr Protein, TrkA Protein, trk Protein, trka Protein, CTRKA Protein, trkA Protein, neurotrophic receptor tyrosine kinase 1 Protein, ret proto-oncogene Protein, neurotrophic tyrosine kinase, receptor, type 1 Protein, NTRK1 Protein, RET Protein, Ntrk1 Protein, ntrk1 Protein
- 背景
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Background: TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors. The presence of NTRK1 leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. It was originally identified as an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas. TRKA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. NTRK1 has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. It also activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway. Defects in NTRK1 are a cause of congenital insensitivity to pain with anhidrosis and thyroid papillary carcinoma.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: C80751;Tkr;trk;TrkA
- 分子量
- 69.2 kDa
- NCBI登录号
- NP_001028296
- 途径
- RTK signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process
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