TLR3 Protein (AA 23-703) (His tag)
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- 抗原 See all TLR3 蛋白
- TLR3 (Toll-Like Receptor 3 (TLR3))
- 蛋白类型
- Recombinant
- 产品特性
- AA 23-703
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This TLR3 protein is labelled with His tag.
- 原理
- Human TLR3 Protein
- 序列
- Ser23-Glu703
- 产品特性
- Recombinant Human TLR3 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ser23-Glu703.
- 纯度
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- 过滤
- 0.22 μm filtered
- 内毒素水平
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human TLR3, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-TLR3 Antibody, hFc Tag with the EC50 of 4.9ng/ml determined by ELISA. See testing image for detail.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- 缓冲液
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- TLR3 (Toll-Like Receptor 3 (TLR3))
- 别名
- TLR3 (TLR3 产品)
- 别名
- CD283 Protein, IIAE2 Protein, AI957183 Protein, zgc:123006 Protein, toll like receptor 3 Protein, toll-like receptor 3 Protein, TLR3 Protein, Tlr3 Protein, tlr3 Protein
- 背景
- TLR3 is expressed in the central nervous system (CNS), where it is required to control HSV-1, which spreads from the epithelium to the CNS via cranial nerves. TLR3 is also expressed in epithelial and dendritic cells, which apparently use TLR3-independent pathways to prevent further dissemination of HSV-1 and to provide resistance to other pathogens in TLR3-deficient patients. Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance of TLR3.
- 分子量
- 78.7 kDa. Due to glycosylation, the protein migrates to 90-115 kDa based on Tris-Bis PAGE result.
- UniProt
- Q6PCD4
- 途径
- TLR signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades
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