TLR3 产品
(Toll-Like Receptor 3 (TLR3))
Categories
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008].
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Featured TLR3 Categories
TLR3 抗体
High quality antibodies with extensive validation data.
TLR3 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
TLR3 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TLR3 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7434491
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (7)
Cat. No.
ABIN6149219
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (4)
- (4)
Cat. No.
ABIN686617
Quantity
100 μL
Datasheet
Datasheet
Recommended TLR3 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (6)
Cat. No.
ABIN6720574
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (1)
Cat. No.
ABIN6960031
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970740
Quantity
96 tests
Datasheet
Datasheet
Recommended TLR3 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (4)
Cat. No.
ABIN7275746
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275748
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cynomolgus
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275745
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our TLR3 Products
: "Bronchial mucosal IFN-α/β and pattern recognition receptor expression in patients with experimental rhinovirus-induced asthma exacerbations." in: The Journal of allergy and clinical immunology, Vol. 143, Issue 1, pp. 114-125.e4, (2019) (PubMed).: "Vinpocetine regulates levels of circulating TLRs in Parkinson's disease patients." in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, Vol. 40, Issue 1, pp. 113-120, (2019) (PubMed).
: "Toll-like receptor 3 controls QT interval on the electrocardiogram by targeting the degradation of Kv4.2/4.3 channels in the endoplasmic reticulum." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 33, Issue 5, pp. 6197-6208, (2019) (PubMed).
: "Loss of TLR3 and its downstream signaling accelerates acinar cell damage in the acute phase of pancreatitis." in: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], Vol. 19, Issue 1, pp. 149-157, (2019) (PubMed).
: "Anti-tumour activity of oncolytic reovirus against canine histiocytic sarcoma cells." in: Veterinary and comparative oncology, Vol. 17, Issue 2, pp. 184-193, (2019) (PubMed).
: "Activation of Toll-like receptor 3 promotes pathological corneal neovascularization by enhancement of SDF-1-mediated endothelial progenitor cell recruitment." in: Experimental eye research, Vol. 178, pp. 177-185, (2019) (PubMed).
: "Calcium/Calmodulin-Dependent Protein Kinase IV Mediates IFN-γ-Induced Immune Behaviors in Skeletal Muscle Cells." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 46, Issue 1, pp. 351-364, (2018) (PubMed).
: "Daily oscillations in expression and responsiveness of Toll-like receptors in splenic immune cells." in: Heliyon, Vol. 4, Issue 3, pp. e00579, (2018) (PubMed).
: "Substance P represents a novel first-line defense mechanism in the nose." in: The Journal of allergy and clinical immunology, (2017) (PubMed).
: "Central role of the TIR-domain-containing adaptor-inducing interferon-β (TRIF) adaptor protein in murine sterile liver injury." in: Hepatology (Baltimore, Md.), Vol. 65, Issue 4, pp. 1336-1351, (2017) (PubMed).
Synonyms and alternative names related to TLR3
toll like receptor 3 (TLR3), toll-like receptor 3 (Tlr3), toll like receptor 3 (Tlr3), toll-like receptor 3 (tlr3), AI957183, CD283, IIAE2, zgc:123006Protein level used designations for TLR3
- toll-like receptor 3
- toll-like receptor 3-like
- toll-like receptor 3 variant 1
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