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CTLA4 Protein (AA 36-161) (Fc Tag)

This Recombinant CTLA4 protein is expressed in HEK-293 Cells.
产品编号 ABIN7274436
发货至: 中国

Quick Overview for CTLA4 Protein (AA 36-161) (Fc Tag) (ABIN7274436)

抗原

See all CTLA4 蛋白
CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

蛋白类型

Recombinant

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HEK-293 Cells

纯度

> 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
  • 产品特性

    AA 36-161

    标记

    This CTLA4 protein is labelled with Fc Tag.

    原理

    Human CTLA-4/CD152 Protein

    序列

    Lys36-Asp161

    产品特性

    Recombinant Human CTLA-4/CD152 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Lys36-Asp161.

    过滤

    0.22 μm filtered

    内毒素水平

    Less than 1EU per μg by the LAL method.

    Biological Activity Comment

    Immobilized Human B7-2, His Tag at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Human CTLA-4, hFc Tag with the EC50 of 0.12μg/ml determined by ELISA. The affinity constant of 1.1nM as determined in SPR assay (Biacore T200). See testing image for detail.
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  • 限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

    缓冲液

    Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

    储存条件

    -20 °C,-80 °C

    储存方法

    -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

    别名

    CTLA-4

    背景

    CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses.CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation - a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.

    分子量

    40.1 kDa. Due to glycosylation, the protein migrates to 50-55 kDa based on Tris-Bis PAGE result.

    UniProt

    P16410-1

    途径

    Cancer Immune Checkpoints
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