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CTLA4 蛋白

(Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008].

Active filters:

  • 抗原: CTLA4
  • Protein
Catalog no. 产品 适用 宿主 / 克隆类型 应用 价格和交货时间
ABIN6961090
CTLA4 Protein (AA 36-161) (His tag,mFc Tag) CTLA4 · Protein 人 HEK-293 Cells
  • SDS (SDS-PAGE: 有验证图片)
  • FACS (Flow Cytometry: 有验证图片)
  • ELISA (ELISA: 有验证图片)
  • AM (Affinity Measurement: 所列应用)
  • ADA (Antibody Drug Assay: 所列应用)
  • IA (Immunoassay: 所列应用)
  • ScA (Screening Assay: 所列应用)
  • 100 μg
  • 10 μg
  • 50 μg
发货至: 中国
ABIN7274437
CTLA4 Protein (AA 36-161) (Biotin,His-Avi Tag) CTLA4 · Protein 人 HEK-293 Cells
  • SDS (SDS-PAGE: 有验证图片)
  • ELISA (ELISA: 有验证图片)
  • SEC-HPLC (Size-exclusion chromatography-High Pressure Liquid Chromatography: 有验证图片)
  • 100 μg
  • 500 μg
发货至: 中国
ABIN6961164
CTLA4 Protein (AA 36-161) (Fc Tag) CTLA4 · Protein 人 HEK-293 Cells
  • SDS (SDS-PAGE: 有验证图片)
  • FACS (Flow Cytometry: 有验证图片)
  • ELISA (ELISA: 有验证图片)
  • AM (Affinity Measurement: 所列应用)
  • ADA (Antibody Drug Assay: 所列应用)
  • IA (Immunoassay: 所列应用)
  • ScA (Screening Assay: 所列应用)
  • 100 μg
  • 10 μg
  • 50 μg
发货至: 中国
ABIN7274434
CTLA4 Protein (AA 37-160) (His tag) CTLA4 · Protein Cynomolgus HEK-293 Cells
  • SDS (SDS-PAGE: 有验证图片)
  • ELISA (ELISA: 有验证图片)
  • SEC-HPLC (Size-exclusion chromatography-High Pressure Liquid Chromatography: 有验证图片)
  • SPR (Surface Plasmon Resonance: 有验证图片)
  • 100 μg
  • 500 μg
发货至: 中国
ABIN7321017
CTLA4 Protein (AA 37-161) (His tag) CTLA4 · Protein 豚鼠 Yeast (Pichia pastoris)
  • ELISA (ELISA: 有验证图片)
  • WB (Western Blotting: 有验证图片)
  • CC (Cell Culture: 所列应用)
  • 50 μg
  • 10 μg
发货至: 中国
ABIN4369863
CTLA4 Protein (AA 37-161) (His-DYKDDDDK-Strep II Tag) CTLA4 · Protein 人 HEK-293T Cells
  • SDS (SDS-PAGE: 有验证图片)
  • WB (Western Blotting: 有验证图片)
  • ELISA (ELISA: 所列应用)
  • PI (Protein Interaction: 所列应用)
  • 2 μg
  • 25 μg
发货至: 中国
ABIN7320509
CTLA4 Protein (AA 37-161) (His tag) CTLA4 · Protein 小鼠 HEK-293 Cells
  • ELISA (ELISA: 有验证图片)
  • WB (Western Blotting: 有验证图片)
  • 50 μg
  • 10 μg
发货至: 中国
ABIN2870729
CTLA4 Protein (AA 36-162) (His tag) CTLA4 · Protein 小鼠 HEK-293 Cells
  • SDS (SDS-PAGE: 有验证图片)
  • Bind (Binding Studies: 有验证图片)
  • 200 μg
  • 1 mg
发货至: 中国
ABIN2487344
CTLA4 Protein (AA 37-162) (His tag) CTLA4 · Protein 人 HEK-293 Cells
  • SDS (SDS-PAGE: 有验证图片)
  • Bind (Binding Studies: 有验证图片)
  • 100 μg
  • 1 mg
  • 200 μg
发货至: 中国
ABIN2870534
CTLA4 Protein (AA 37-162) (Fc Tag,AVI tag,Biotin) CTLA4 · Protein 人 HEK-293 Cells
  • SDS (SDS-PAGE: 有验证图片)
  • Bind (Binding Studies: 有验证图片)
  • 200 μg
  • 25 μg
发货至: 中国
ABIN7092855
CTLA4 Protein (AA 36-162) (Fc Tag) CTLA4 · Protein 小鼠 HEK-293 Cells
  • SDS (SDS-PAGE: 有验证图片)
  • AM (Affinity Measurement: 所列应用)
  • ADA (Antibody Drug Assay: 所列应用)
  • IA (Immunoassay: 所列应用)
  • ScA (Screening Assay: 所列应用)
  • 100 μg
  • 10 μg
  • 50 μg
发货至: 中国
ABIN2128753
CTLA4 蛋白 CTLA4 · Protein 人 大肠杆菌(E. Coli)
  • SDS (SDS-PAGE: 有验证图片)
  • 100 μg
发货至: 中国
ABIN7195370
CTLA4 Protein (AA 1-161, Extracellular Domain) (His tag) CTLA4 · Protein 大鼠 HEK-293 Cells
  • WB (Western Blotting: 有验证图片)
  • 100 μg
发货至: 中国
ABIN7320970
CTLA4 Protein (AA 37-160) (Fc Tag) CTLA4 · Protein Cynomolgus HEK-293 Cells
  • WB (Western Blotting: 有验证图片)
  • 50 μg
  • 10 μg
发货至: 中国
ABIN1350656
CTLA4 Protein (AA 36-135) (GST tag) CTLA4 · Protein 人 小麦胚
  • AP (Affinity Purification: 所列应用)
  • AA (Antibody Array: 所列应用)
  • ELISA (ELISA: 所列应用)
  • WB (Western Blotting: 所列应用)
  • 10 μg
  • 2 μg
  • 25 μg
发货至: 中国
ABIN7320508
CTLA4 Protein (AA 37-161) (DYKDDDDK Tag) CTLA4 · Protein 小鼠 HEK-293 Cells
  • WB (Western Blotting: 有验证图片)
  • 50 μg
  • 10 μg
发货至: 中国
ABIN2870731
CTLA4 Protein (AA 36-162) (Fc Tag) CTLA4 · Protein 小鼠 HEK-293 Cells
  • SDS (SDS-PAGE: 有验证图片)
  • Bind (Binding Studies: 有验证图片)
  • 200 μg
  • 1 mg
发货至: 中国
ABIN6810026
CTLA4 Protein (AA 37-162) (Strep Tag) CTLA4 · Protein 人 HEK-293 Cells
  • SDS (SDS-PAGE: 有验证图片)
  • Bind (Binding Studies: 有验证图片)
  • 1 mg
  • 25 μg
  • 250 μg
发货至: 中国
ABIN2180929
CTLA4 Protein (AA 37-160) (His tag,AVI tag,Biotin) CTLA4 · Protein Cynomolgus, 猕猴 HEK-293 Cells
  • SDS (SDS-PAGE: 有验证图片)
  • ELISA (ELISA: 有验证图片)
  • 200 μg
  • 25 μg
  • 50 μg
发货至: 中国
ABIN2180926
CTLA4 Protein (AA 37-160) (His tag) CTLA4 · Protein Cynomolgus, 猕猴 HEK-293 Cells
  • SDS (SDS-PAGE: 有验证图片)
  • ELISA (ELISA: 有验证图片)
  • 200 μg
  • 1 mg
发货至: 中国
Protein
  • SDS (SDS-PAGE: 有验证图片)
  • FACS (Flow Cytometry: 有验证图片)
  • ELISA (ELISA: 有验证图片)
  • AM (Affinity Measurement: 所列应用)
  • ADA (Antibody Drug Assay: 所列应用)
  • IA (Immunoassay: 所列应用)
  • ScA (Screening Assay: 所列应用)
宿主
人
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
产品编号 ABIN6961090
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • SDS (SDS-PAGE: 有验证图片)
  • ELISA (ELISA: 有验证图片)
  • SEC-HPLC (Size-exclusion chromatography-High Pressure Liquid Chromatography: 有验证图片)
宿主
人
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
> 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
生物活性
Active
产品编号 ABIN7274437
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • SDS (SDS-PAGE: 有验证图片)
  • FACS (Flow Cytometry: 有验证图片)
  • ELISA (ELISA: 有验证图片)
  • AM (Affinity Measurement: 所列应用)
  • ADA (Antibody Drug Assay: 所列应用)
  • IA (Immunoassay: 所列应用)
  • ScA (Screening Assay: 所列应用)
宿主
人
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
产品编号 ABIN6961164
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • SDS (SDS-PAGE: 有验证图片)
  • ELISA (ELISA: 有验证图片)
  • SEC-HPLC (Size-exclusion chromatography-High Pressure Liquid Chromatography: 有验证图片)
  • SPR (Surface Plasmon Resonance: 有验证图片)
宿主
Cynomolgus
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
> 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
生物活性
Active
产品编号 ABIN7274434
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • ELISA (ELISA: 有验证图片)
  • WB (Western Blotting: 有验证图片)
  • CC (Cell Culture: 所列应用)
宿主
豚鼠
宿主
Yeast (Pichia pastoris)
蛋白类型
Recombinant
纯度
> 90 % as determined by reducing SDS-PAGE.
生物活性
Active
产品编号 ABIN7321017
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • SDS (SDS-PAGE: 有验证图片)
  • WB (Western Blotting: 有验证图片)
  • ELISA (ELISA: 所列应用)
  • PI (Protein Interaction: 所列应用)
宿主
人
宿主
HEK-293T Cells
蛋白类型
Recombinant
产品编号 ABIN4369863
Protein
  • ELISA (ELISA: 有验证图片)
  • WB (Western Blotting: 有验证图片)
宿主
小鼠
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
> 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7320509
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • SDS (SDS-PAGE: 有验证图片)
  • Bind (Binding Studies: 有验证图片)
宿主
小鼠
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % as determined by SDS-PAGE.
生物活性
Active
产品编号 ABIN2870729
200 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • SDS (SDS-PAGE: 有验证图片)
  • Bind (Binding Studies: 有验证图片)
宿主
人
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % as determined by SDS-PAGE.
生物活性
Active
产品编号 ABIN2487344
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • SDS (SDS-PAGE: 有验证图片)
  • Bind (Binding Studies: 有验证图片)
宿主
人
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % as determined by reduced SDS-PAGE.
生物活性
Active
产品编号 ABIN2870534
200 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • SDS (SDS-PAGE: 有验证图片)
  • AM (Affinity Measurement: 所列应用)
  • ADA (Antibody Drug Assay: 所列应用)
  • IA (Immunoassay: 所列应用)
  • ScA (Screening Assay: 所列应用)
宿主
小鼠
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
产品编号 ABIN7092855
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • SDS (SDS-PAGE: 有验证图片)
宿主
人
宿主
大肠杆菌(E. Coli)
蛋白类型
Recombinant
产品编号 ABIN2128753
Protein
  • WB (Western Blotting: 有验证图片)
宿主
大鼠
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
> 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7195370
Protein
  • WB (Western Blotting: 有验证图片)
宿主
Cynomolgus
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
> 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7320970
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • AP (Affinity Purification: 所列应用)
  • AA (Antibody Array: 所列应用)
  • ELISA (ELISA: 所列应用)
  • WB (Western Blotting: 所列应用)
宿主
人
宿主
小麦胚
蛋白类型
Recombinant
产品编号 ABIN1350656
Protein
  • WB (Western Blotting: 有验证图片)
宿主
小鼠
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
> 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7320508
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • SDS (SDS-PAGE: 有验证图片)
  • Bind (Binding Studies: 有验证图片)
宿主
小鼠
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % as determined by SDS-PAGE.
生物活性
Active
产品编号 ABIN2870731
200 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • SDS (SDS-PAGE: 有验证图片)
  • Bind (Binding Studies: 有验证图片)
宿主
人
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % as determined by SDS-PAGE.
生物活性
Active
产品编号 ABIN6810026
1 mg (More quantities available)
发货至: 中国
获取报价
Protein
  • SDS (SDS-PAGE: 有验证图片)
  • ELISA (ELISA: 有验证图片)
宿主
Cynomolgus, 猕猴
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % as determined by SDS-PAGE.
生物活性
Active
产品编号 ABIN2180929
200 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • SDS (SDS-PAGE: 有验证图片)
  • ELISA (ELISA: 有验证图片)
宿主
Cynomolgus, 猕猴
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % as determined by SDS-PAGE.
生物活性
Active
产品编号 ABIN2180926
200 μg (More quantities available)
发货至: 中国
获取报价

Latest Publications for our CTLA4 蛋白

Bai, Gao, Hu, Liu, Li, Dong, Huang, Zhu, Zhou, Li, Shao: "Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth." in: Molecular therapy oncolytics, Vol. 17, pp. 9-20, (2020) (PubMed).

Simons, Lim, Carter, Wagner, Wayham, Adler, Johnson: "Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR." in: mAbs, Vol. 12, Issue 1, pp. 1803646, (2020) (PubMed).

Okada, Kajiya, Omata, Matsumoto, Sato, Kobayashi, Nakamura, Kaneko, Nakamura, Koyama, Sudo, Shin, Okamoto, Watanabe, Tachibana, Hirose, Saito, Takai, Matsumoto, Nakamura, Okabe, Miyamoto, Tanaka: "CTLA4-Ig Directly Inhibits Osteoclastogenesis by Interfering With Intracellular Calcium Oscillations in Bone Marrow Macrophages." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, (2019) (PubMed).

Ganesan, Moon, Barakat: "Revealing the atomistic details behind the binding of B7-1 to CD28 and CTLA-4: A comprehensive protein-protein modelling study." in: Biochimica et biophysica acta. General subjects, Vol. 1862, Issue 12, pp. 2764-2778, (2019) (PubMed).

Galstyan, Markman, Shatalova, Chiechi, Korman, Patil, Klymyshyn, Tourtellotte, Israel, Braubach, Ljubimov, Mashouf, Ramesh, Grodzinski, Penichet, Black, Holler, Sun, Ding, Ljubimov, Ljubimova: "Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy." in: Nature communications, Vol. 10, Issue 1, pp. 3850, (2019) (PubMed).

Gonzalez-Nieto, Castro, Bischof, Shin, Ricciardi, Bailey, Dang, Pedreño-Lopez, Magnani, Ejima, Allison, Gil, Evans, Rakasz, Lifson, Desrosiers, Martins: "Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques." in: PLoS pathogens, Vol. 15, Issue 9, pp. e1008015, (2019) (PubMed).

Ganesan, Ahmed, Okoye, Arutyunova, Babu, Turnbull, Kundu, Shields, Agopsowicz, Xu, Tabana, Srivastava, Zhang, Moon, Belovodskiy, Hena, Kandadai, Hosseini, Hitt, Walker, Smylie, West, Siraki, Lemieux et al.: "Comprehensive in vitro characterization of PD-L1 small molecule inhibitors. ..." in: Scientific reports, Vol. 9, Issue 1, pp. 12392, (2019) (PubMed).

Zhao, Lee, Lin, Gassen, Xu, Huang, Xiao, Bonorino, Lu, Bui, Hui: "PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways." in: Immunity, Vol. 51, Issue 6, pp. 1059-1073.e9, (2019) (PubMed).

Waight, Chand, Dietrich, Gombos, Horn, Gonzalez, Manrique, Swiech, Morin, Brittsan, Tanne, Akpeng, Croker, Buell, Stein, Savitsky, Wilson: "Selective FcγR Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens." in: Cancer cell, Vol. 33, Issue 6, pp. 1033-1047.e5, (2019) (PubMed).

Ljungars, Svensson, Carlsson, Birgersson, Tornberg, Frendéus, Ohlin, Mattsson: "Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes." in: Frontiers in pharmacology, Vol. 10, pp. 847, (2019) (PubMed).

Aliases for CTLA4 蛋白

cytotoxic T-lymphocyte associated protein 4 (CTLA4) 蛋白
cytotoxic T-lymphocyte-associated protein 4 (Ctla4) 蛋白
CD 蛋白
CD152 蛋白
Cd152 蛋白
CELIAC3 蛋白
CTLA-4 蛋白
Ctla-4 蛋白
CTLA4 蛋白
GRD4 蛋白
GSE 蛋白
IDDM12 蛋白
Ly-56 蛋白
sCTLA4 蛋白
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