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CTLA4 蛋白

(Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008].

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  • 抗原: CTLA4
  • Protein
Catalog no. 产品 适用 宿主 / 克隆类型 应用 价格和交货时间
ABIN1658753
CTLA4 Protein (AA 36-161) (His tag) CTLA4 · Protein 犬 酵母菌
  • ELISA (ELISA: 所列应用)
  • 1 mg
发货至: 中国
ABIN1657272
CTLA4 Protein (AA 38-161) (His tag) CTLA4 · Protein Pig 酵母菌
  • ELISA (ELISA: 所列应用)
  • 1 mg
发货至: 中国
ABIN1473232
CTLA4 Protein (AA 38-161) (His tag) CTLA4 · Protein 兔 酵母菌
  • ELISA (ELISA: 所列应用)
  • 1 mg
发货至: 中国
ABIN2566479
CTLA4 Protein (His tag) CTLA4 · Protein Cynomolgus, 猕猴 HEK-293 Cells
  • WB (Western Blotting: 所列应用)
  • 200 μg
发货至: 中国
ABIN7955395
CTLA4 Protein (Strep Tag) CTLA4 · Protein Treeshrew (Tupaia) Mammalian Cells
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • Imm (Immunogen: 所列应用)
  • 100 μg
  • 1 mg
  • 50 μg
发货至: 中国
ABIN7955397
CTLA4 Protein (Fc Tag) CTLA4 · Protein Treeshrew (Tupaia) Mammalian Cells
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • Imm (Immunogen: 所列应用)
  • 100 μg
  • 1 mg
  • 50 μg
发货至: 中国
ABIN7963118
CTLA4 Protein (partial) (His-SUMO Tag,MYC tag) CTLA4 · Protein 小鼠 大肠杆菌(E. Coli)
  • 100 μg
  • 1 mg
  • 20 μg
发货至: 中国
ABIN5608347
CTLA4 Protein (partial) (Fc Tag) CTLA4 · Protein 人 HEK-293 Cells
  • WB (Western Blotting: 所列应用)
  • 100 μg
发货至: 中国
ABIN5608349
CTLA4 Protein (partial) (Fc Tag) CTLA4 · Protein 小鼠 HEK-293 Cells
  • WB (Western Blotting: 所列应用)
  • ELISA (ELISA: 所列应用)
  • 200 μg
发货至: 中国
ABIN5608352
CTLA4 Protein (partial) (Fc Tag) CTLA4 · Protein 大鼠 HEK-293 Cells
  • WB (Western Blotting: 所列应用)
  • ELISA (ELISA: 所列应用)
  • 100 μg
发货至: 中国
ABIN5608348
CTLA4 Protein (partial) (His tag) CTLA4 · Protein 小鼠 HEK-293 Cells
  • WB (Western Blotting: 所列应用)
  • ELISA (ELISA: 所列应用)
  • 200 μg
发货至: 中国
ABIN5608351
CTLA4 Protein (partial) (Fc Tag) CTLA4 · Protein 兔 HEK-293 Cells
  • WB (Western Blotting: 所列应用)
  • 100 μg
发货至: 中国
ABIN7820532
CTLA4 Protein (AA 38-161) (Strep Tag) CTLA4 · Protein Treeshrew (Tupaia) Eukaryota
  • 100 μg
发货至: 中国
ABIN7314128
CTLA4 Protein (AA 36-161) (Fc Tag,AVI tag) CTLA4 · Protein 人 人细胞
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • MS (Mass Spectrometry: 所列应用)
  • 50 μg
  • 10 μg
  • 500 μg
发货至: 中国
ABIN7314124
CTLA4 Protein (AA 37-161) (His tag) CTLA4 · Protein 人 人细胞
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • MS (Mass Spectrometry: 所列应用)
  • 50 μg
  • 10 μg
  • 500 μg
发货至: 中国
ABIN2747619
CTLA4 蛋白 CTLA4 · Protein 人, 小鼠, 大鼠 大肠杆菌(E. Coli)
  • WB (Western Blotting: 所列应用)
  • PC (Positive Control: 所列应用)
  • 5 applications
发货至: 中国
ABIN7314132
CTLA4 Protein (AA 36-161) (GST tag) CTLA4 · Protein 人 人细胞
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • MS (Mass Spectrometry: 所列应用)
  • 50 μg
  • 10 μg
  • 500 μg
发货至: 中国
ABIN7961553
CTLA4 Protein (GST tag) CTLA4 · Protein 人 人细胞
  • 50 μg
  • 1 mg
  • 500 μg
发货至: 中国
ABIN7314130
CTLA4 Protein (AA 36-161) (DYKDDDDK Tag) CTLA4 · Protein 人 人细胞
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • MS (Mass Spectrometry: 所列应用)
  • 50 μg
  • 10 μg
  • 500 μg
发货至: 中国
ABIN7953825
CTLA4 Protein (His tag) CTLA4 · Protein 小鼠 大肠杆菌(E. Coli)
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • Imm (Immunogen: 所列应用)
  • 100 μg
  • 1 mg
  • 50 μg
发货至: 中国
Protein
  • ELISA (ELISA: 所列应用)
宿主
犬
宿主
酵母菌
蛋白类型
Recombinant
纯度
> 90 %
产品编号 ABIN1658753
Protein
  • ELISA (ELISA: 所列应用)
宿主
Pig
宿主
酵母菌
蛋白类型
Recombinant
纯度
> 90 %
产品编号 ABIN1657272
Protein
  • ELISA (ELISA: 所列应用)
宿主
兔
宿主
酵母菌
蛋白类型
Recombinant
纯度
> 90 %
产品编号 ABIN1473232
Protein
  • WB (Western Blotting: 所列应用)
宿主
Cynomolgus, 猕猴
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % as determined by SDS-PAGE.
产品编号 ABIN2566479
Protein
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • Imm (Immunogen: 所列应用)
宿主
Treeshrew (Tupaia)
宿主
Mammalian Cells
蛋白类型
Recombinant
产品编号 ABIN7955395
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • Imm (Immunogen: 所列应用)
宿主
Treeshrew (Tupaia)
宿主
Mammalian Cells
蛋白类型
Recombinant
产品编号 ABIN7955397
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
小鼠
宿主
大肠杆菌(E. Coli)
蛋白类型
Recombinant
纯度
Greater than 90 % as determined by SDS-PAGE.
产品编号 ABIN7963118
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • WB (Western Blotting: 所列应用)
宿主
人
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % as determined by SDS-PAGE.
产品编号 ABIN5608347
Protein
  • WB (Western Blotting: 所列应用)
  • ELISA (ELISA: 所列应用)
宿主
小鼠
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % as determined by SDS-PAGE.
生物活性
Active
产品编号 ABIN5608349
Protein
  • WB (Western Blotting: 所列应用)
  • ELISA (ELISA: 所列应用)
宿主
大鼠
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % as determined by SDS-PAGE.
生物活性
Active
产品编号 ABIN5608352
Protein
  • WB (Western Blotting: 所列应用)
  • ELISA (ELISA: 所列应用)
宿主
小鼠
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % as determined by SDS-PAGE.
生物活性
Active
产品编号 ABIN5608348
Protein
  • WB (Western Blotting: 所列应用)
宿主
兔
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % as determined by SDS-PAGE.
产品编号 ABIN5608351
Protein
宿主
Treeshrew (Tupaia)
宿主
Eukaryota
蛋白类型
Recombinant
产品编号 ABIN7820532
Protein
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • MS (Mass Spectrometry: 所列应用)
宿主
人
宿主
人细胞
蛋白类型
Recombinant
纯度
Greater than 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7314128
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • MS (Mass Spectrometry: 所列应用)
宿主
人
宿主
人细胞
蛋白类型
Recombinant
纯度
Greater than 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7314124
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • WB (Western Blotting: 所列应用)
  • PC (Positive Control: 所列应用)
宿主
人, 小鼠, 大鼠
宿主
大肠杆菌(E. Coli)
蛋白类型
Recombinant
产品编号 ABIN2747619
5 applications
发货至: 中国
获取报价
Protein
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • MS (Mass Spectrometry: 所列应用)
宿主
人
宿主
人细胞
蛋白类型
Recombinant
纯度
Greater than 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7314132
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
人
宿主
人细胞
蛋白类型
Recombinant
纯度
Greater than 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7961553
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • MS (Mass Spectrometry: 所列应用)
宿主
人
宿主
人细胞
蛋白类型
Recombinant
纯度
Greater than 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7314130
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • Imm (Immunogen: 所列应用)
宿主
小鼠
宿主
大肠杆菌(E. Coli)
蛋白类型
Recombinant
产品编号 ABIN7953825
100 μg (More quantities available)
发货至: 中国
获取报价

Latest Publications for our CTLA4 蛋白

Bai, Gao, Hu, Liu, Li, Dong, Huang, Zhu, Zhou, Li, Shao: "Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth." in: Molecular therapy oncolytics, Vol. 17, pp. 9-20, (2020) (PubMed).

Simons, Lim, Carter, Wagner, Wayham, Adler, Johnson: "Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR." in: mAbs, Vol. 12, Issue 1, pp. 1803646, (2020) (PubMed).

Okada, Kajiya, Omata, Matsumoto, Sato, Kobayashi, Nakamura, Kaneko, Nakamura, Koyama, Sudo, Shin, Okamoto, Watanabe, Tachibana, Hirose, Saito, Takai, Matsumoto, Nakamura, Okabe, Miyamoto, Tanaka: "CTLA4-Ig Directly Inhibits Osteoclastogenesis by Interfering With Intracellular Calcium Oscillations in Bone Marrow Macrophages." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, (2019) (PubMed).

Ganesan, Moon, Barakat: "Revealing the atomistic details behind the binding of B7-1 to CD28 and CTLA-4: A comprehensive protein-protein modelling study." in: Biochimica et biophysica acta. General subjects, Vol. 1862, Issue 12, pp. 2764-2778, (2019) (PubMed).

Galstyan, Markman, Shatalova, Chiechi, Korman, Patil, Klymyshyn, Tourtellotte, Israel, Braubach, Ljubimov, Mashouf, Ramesh, Grodzinski, Penichet, Black, Holler, Sun, Ding, Ljubimov, Ljubimova: "Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy." in: Nature communications, Vol. 10, Issue 1, pp. 3850, (2019) (PubMed).

Gonzalez-Nieto, Castro, Bischof, Shin, Ricciardi, Bailey, Dang, Pedreño-Lopez, Magnani, Ejima, Allison, Gil, Evans, Rakasz, Lifson, Desrosiers, Martins: "Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques." in: PLoS pathogens, Vol. 15, Issue 9, pp. e1008015, (2019) (PubMed).

Ganesan, Ahmed, Okoye, Arutyunova, Babu, Turnbull, Kundu, Shields, Agopsowicz, Xu, Tabana, Srivastava, Zhang, Moon, Belovodskiy, Hena, Kandadai, Hosseini, Hitt, Walker, Smylie, West, Siraki, Lemieux et al.: "Comprehensive in vitro characterization of PD-L1 small molecule inhibitors. ..." in: Scientific reports, Vol. 9, Issue 1, pp. 12392, (2019) (PubMed).

Zhao, Lee, Lin, Gassen, Xu, Huang, Xiao, Bonorino, Lu, Bui, Hui: "PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways." in: Immunity, Vol. 51, Issue 6, pp. 1059-1073.e9, (2019) (PubMed).

Waight, Chand, Dietrich, Gombos, Horn, Gonzalez, Manrique, Swiech, Morin, Brittsan, Tanne, Akpeng, Croker, Buell, Stein, Savitsky, Wilson: "Selective FcγR Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens." in: Cancer cell, Vol. 33, Issue 6, pp. 1033-1047.e5, (2019) (PubMed).

Ljungars, Svensson, Carlsson, Birgersson, Tornberg, Frendéus, Ohlin, Mattsson: "Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes." in: Frontiers in pharmacology, Vol. 10, pp. 847, (2019) (PubMed).

Aliases for CTLA4 蛋白

cytotoxic T-lymphocyte associated protein 4 (CTLA4) 蛋白
cytotoxic T-lymphocyte-associated protein 4 (Ctla4) 蛋白
CD 蛋白
CD152 蛋白
Cd152 蛋白
CELIAC3 蛋白
CTLA-4 蛋白
Ctla-4 蛋白
CTLA4 蛋白
GRD4 蛋白
GSE 蛋白
IDDM12 蛋白
Ly-56 蛋白
sCTLA4 蛋白
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