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CTLA4 蛋白

(Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008].

Active filters:

  • 抗原: CTLA4
  • Protein
Catalog no. 产品 适用 宿主 / 克隆类型 应用 价格和交货时间
ABIN7941921
CTLA4 Protein (His tag) CTLA4 · Protein 人 大肠杆菌(E. Coli)
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • Imm (Immunogen: 所列应用)
  • 100 μg
  • 1 mg
  • 50 μg
发货至: 中国
ABIN7949937
CTLA4 Protein (His tag) CTLA4 · Protein 小鼠 Mammalian Cells
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • Imm (Immunogen: 所列应用)
  • 100 μg
  • 1 mg
  • 50 μg
发货至: 中国
ABIN7941923
CTLA4 Protein (His tag) CTLA4 · Protein 人 Mammalian Cells
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • Imm (Immunogen: 所列应用)
  • 100 μg
  • 1 mg
  • 50 μg
发货至: 中国
ABIN7961663
CTLA4 Protein (DYKDDDDK Tag) CTLA4 · Protein 人 人细胞
  • 50 μg
  • 1 mg
  • 500 μg
发货至: 中国
ABIN7961477
CTLA4 Protein (His tag) CTLA4 · Protein 小鼠 人细胞
  • 50 μg
  • 1 mg
  • 500 μg
发货至: 中国
ABIN7961475
CTLA4 Protein (His tag) CTLA4 · Protein 人 人细胞
  • 50 μg
  • 1 mg
  • 500 μg
发货至: 中国
ABIN7960981
CTLA4 Protein (Fc Tag) CTLA4 · Protein 人 人细胞
  • 50 μg
  • 1 mg
  • 500 μg
发货至: 中国
ABIN7960927
CTLA4 Protein (His tag) CTLA4 · Protein 豚鼠 Yeast (Pichia pastoris)
  • 50 μg
  • 1 mg
  • 500 μg
发货至: 中国
ABIN7961729
CTLA4 Protein (Fc-Avi Tag) CTLA4 · Protein 人 人细胞
  • 50 μg
  • 1 mg
  • 500 μg
发货至: 中国
ABIN7819790
CTLA4 Protein (AA 35-153) (His tag) CTLA4 · Protein 小鼠 Bacteria
  • 100 μg
发货至: 中国
ABIN7820531
CTLA4 Protein (AA 38-161) (Fc Tag) CTLA4 · Protein Treeshrew (Tupaia) Eukaryota
  • 100 μg
发货至: 中国
ABIN7271621
CTLA4 Protein (His tag) CTLA4 · Protein 大鼠 HEK-293 Cells
  • 100 μg
  • 1 mg
发货至: 中国
ABIN2713438
CTLA4 Protein (Transcript Variant 1) (Fc Tag) CTLA4 · Protein 人 CHO Cells
  • Func (Functional Studies: 所列应用)
  • AbP (Antibody Production: 所列应用)
  • STD (Standard: 所列应用)
  • PI (Protein Interaction: 所列应用)
  • 10 μg
发货至: 中国
ABIN7446002
CTLA4 Protein (Transcript Variant 1) (Fc Tag) CTLA4 · Protein 人 HEK-293 Cells
  • AbP (Antibody Production: 所列应用)
  • STD (Standard: 所列应用)
  • 10 μg
  • 50 μg
发货至: 中国
Protein
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • Imm (Immunogen: 所列应用)
宿主
人
宿主
大肠杆菌(E. Coli)
蛋白类型
Recombinant
产品编号 ABIN7941921
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • Imm (Immunogen: 所列应用)
宿主
小鼠
宿主
Mammalian Cells
蛋白类型
Recombinant
产品编号 ABIN7949937
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • Imm (Immunogen: 所列应用)
宿主
人
宿主
Mammalian Cells
蛋白类型
Recombinant
产品编号 ABIN7941923
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
人
宿主
人细胞
蛋白类型
Recombinant
纯度
Greater than 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7961663
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
小鼠
宿主
人细胞
蛋白类型
Recombinant
纯度
Greater than 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7961477
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
人
宿主
人细胞
蛋白类型
Recombinant
纯度
Greater than 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7961475
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
人
宿主
人细胞
蛋白类型
Recombinant
纯度
Greater than 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7960981
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
豚鼠
宿主
Yeast (Pichia pastoris)
蛋白类型
Recombinant
纯度
Greater than 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7960927
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
人
宿主
人细胞
蛋白类型
Recombinant
纯度
Greater than 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7961729
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
小鼠
宿主
Bacteria
蛋白类型
Recombinant
产品编号 ABIN7819790
Protein
宿主
Treeshrew (Tupaia)
宿主
Eukaryota
蛋白类型
Recombinant
产品编号 ABIN7820531
Protein
宿主
大鼠
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>90 % as determined by SDS-PAGE.
产品编号 ABIN7271621
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • Func (Functional Studies: 所列应用)
  • AbP (Antibody Production: 所列应用)
  • STD (Standard: 所列应用)
  • PI (Protein Interaction: 所列应用)
宿主
人
宿主
CHO Cells
蛋白类型
Recombinant
纯度
> 95 % , as determined by Coomassie stained SDS-PAGE
生物活性
Active
产品编号 ABIN2713438
Protein
  • AbP (Antibody Production: 所列应用)
  • STD (Standard: 所列应用)
宿主
人
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
> 95 % as determined by SDS-PAGE and Coomassie blue staining
产品编号 ABIN7446002

Latest Publications for our CTLA4 蛋白

Bai, Gao, Hu, Liu, Li, Dong, Huang, Zhu, Zhou, Li, Shao: "Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth." in: Molecular therapy oncolytics, Vol. 17, pp. 9-20, (2020) (PubMed).

Simons, Lim, Carter, Wagner, Wayham, Adler, Johnson: "Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR." in: mAbs, Vol. 12, Issue 1, pp. 1803646, (2020) (PubMed).

Okada, Kajiya, Omata, Matsumoto, Sato, Kobayashi, Nakamura, Kaneko, Nakamura, Koyama, Sudo, Shin, Okamoto, Watanabe, Tachibana, Hirose, Saito, Takai, Matsumoto, Nakamura, Okabe, Miyamoto, Tanaka: "CTLA4-Ig Directly Inhibits Osteoclastogenesis by Interfering With Intracellular Calcium Oscillations in Bone Marrow Macrophages." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, (2019) (PubMed).

Ganesan, Moon, Barakat: "Revealing the atomistic details behind the binding of B7-1 to CD28 and CTLA-4: A comprehensive protein-protein modelling study." in: Biochimica et biophysica acta. General subjects, Vol. 1862, Issue 12, pp. 2764-2778, (2019) (PubMed).

Galstyan, Markman, Shatalova, Chiechi, Korman, Patil, Klymyshyn, Tourtellotte, Israel, Braubach, Ljubimov, Mashouf, Ramesh, Grodzinski, Penichet, Black, Holler, Sun, Ding, Ljubimov, Ljubimova: "Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy." in: Nature communications, Vol. 10, Issue 1, pp. 3850, (2019) (PubMed).

Gonzalez-Nieto, Castro, Bischof, Shin, Ricciardi, Bailey, Dang, Pedreño-Lopez, Magnani, Ejima, Allison, Gil, Evans, Rakasz, Lifson, Desrosiers, Martins: "Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques." in: PLoS pathogens, Vol. 15, Issue 9, pp. e1008015, (2019) (PubMed).

Ganesan, Ahmed, Okoye, Arutyunova, Babu, Turnbull, Kundu, Shields, Agopsowicz, Xu, Tabana, Srivastava, Zhang, Moon, Belovodskiy, Hena, Kandadai, Hosseini, Hitt, Walker, Smylie, West, Siraki, Lemieux et al.: "Comprehensive in vitro characterization of PD-L1 small molecule inhibitors. ..." in: Scientific reports, Vol. 9, Issue 1, pp. 12392, (2019) (PubMed).

Zhao, Lee, Lin, Gassen, Xu, Huang, Xiao, Bonorino, Lu, Bui, Hui: "PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways." in: Immunity, Vol. 51, Issue 6, pp. 1059-1073.e9, (2019) (PubMed).

Waight, Chand, Dietrich, Gombos, Horn, Gonzalez, Manrique, Swiech, Morin, Brittsan, Tanne, Akpeng, Croker, Buell, Stein, Savitsky, Wilson: "Selective FcγR Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens." in: Cancer cell, Vol. 33, Issue 6, pp. 1033-1047.e5, (2019) (PubMed).

Ljungars, Svensson, Carlsson, Birgersson, Tornberg, Frendéus, Ohlin, Mattsson: "Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes." in: Frontiers in pharmacology, Vol. 10, pp. 847, (2019) (PubMed).

Aliases for CTLA4 蛋白

cytotoxic T-lymphocyte associated protein 4 (CTLA4) 蛋白
cytotoxic T-lymphocyte-associated protein 4 (Ctla4) 蛋白
CD 蛋白
CD152 蛋白
Cd152 蛋白
CELIAC3 蛋白
CTLA-4 蛋白
Ctla-4 蛋白
CTLA4 蛋白
GRD4 蛋白
GSE 蛋白
IDDM12 蛋白
Ly-56 蛋白
sCTLA4 蛋白
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