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CTLA4 蛋白

(Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008].

Active filters:

  • 抗原: CTLA4
  • Protein
Catalog no. 产品 适用 宿主 / 克隆类型 应用 价格和交货时间
ABIN6973042
CTLA4 Protein (AA 36-162) (His tag,AVI tag,Biotin) CTLA4 · Protein 小鼠 HEK-293 Cells
  • SDS (SDS-PAGE: 有验证图片)
  • ELISA (ELISA: 有验证图片)
  • 200 μg
  • 25 μg
发货至: 中国
ABIN7678665
CTLA4 Protein (AA 37-162) (His-Fc tag) CTLA4 · Protein 小鼠 Mammalian Cells
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • Imm (Immunogen: 所列应用)
  • AcA (Activity Assay: 所列应用)
  • 100 μg
  • 50 μg
发货至: 中国
ABIN6253373
CTLA4 Protein (AA 37-160, Extracellular Domain, N-Term) (Fc Tag) CTLA4 · Protein 人 CHO Cells
  • 100 μg
  • 500 μg
  • 992 g
  • 997 g
发货至: 中国
ABIN7566054
CTLA4 Protein (AA 36-161, C-Term) (His tag) CTLA4 · Protein 人 HEK-293 Cells
  • 50 μg
发货至: 中国
ABIN6253376
CTLA4 Protein (AA 38-160, Extracellular Domain, N-Term) (Fc Tag) CTLA4 · Protein 小鼠 NS1 Cells
  • 100 μg
  • 500 μg
  • 992 g
  • 997 g
发货至: 中国
ABIN7566055
CTLA4 Protein (AA 36-161) CTLA4 · Protein 人 HEK-293 Cells
  • 50 μg
发货至: 中国
ABIN7865809
CTLA4 Protein (His-Avi Tag,Biotin) CTLA4 · Protein 人 HEK-293 Cells
  • 50 μg
发货至: 中国
ABIN7677079
CTLA4 Protein (AA 36-161) (hIgG-His-tag) CTLA4 · Protein 人 Baculovirus infected Insect Cells
  • SDS (SDS-PAGE: 所列应用)
  • AcA (Activity Assay: 所列应用)
  • 100 μg
  • 10 μg
  • 20 μg
  • 50 μg
  • 250 μg
  • 500 μg
发货至: 中国
ABIN7677098
CTLA4 Protein (AA 36-161) (His tag) CTLA4 · Protein 人 Baculovirus infected Insect Cells
  • SDS (SDS-PAGE: 所列应用)
  • AcA (Activity Assay: 所列应用)
  • 100 μg
  • 10 μg
  • 20 μg
  • 50 μg
  • 250 μg
发货至: 中国
ABIN7705450
CTLA4 Protein (AA 37-161) (Fc Tag) CTLA4 · Protein 小鼠 Mammalian Cells
  • WB (Western Blotting: 所列应用)
  • ELISA (ELISA: 所列应用)
  • 50 μg
  • 1 mg
  • 10 μg
  • 500 μg
发货至: 中国
ABIN7677665
CTLA4 Protein (AA 38-161) (hIgG-His-tag) CTLA4 · Protein 小鼠 Baculovirus infected Insect Cells
  • SDS (SDS-PAGE: 所列应用)
  • AcA (Activity Assay: 所列应用)
  • 100 μg
  • 10 μg
  • 20 μg
  • 50 μg
  • 250 μg
  • 500 μg
发货至: 中国
ABIN6573161
CTLA4 Protein (AA 37-161) (His tag) CTLA4 · Protein 豚鼠 Yeast (Pichia pastoris)
  • 50 μg
  • 1 mg
  • 10 μg
  • 500 μg
发货至: 中国
ABIN4372067
CTLA4 Protein (AA 36-161) (His tag) CTLA4 · Protein 人 人细胞
  • 50 μg
  • 1 mg
  • 10 μg
  • 500 μg
发货至: 中国
ABIN6573777
CTLA4 Protein (AA 36-161) (Fc-Avi Tag) CTLA4 · Protein 人 人细胞
  • 50 μg
  • 1 mg
  • 10 μg
  • 500 μg
发货至: 中国
ABIN2115489
CTLA4 Protein (AA 36-161) (Fc Tag) CTLA4 · Protein 人 人细胞
  • 50 μg
  • 1 mg
  • 10 μg
  • 500 μg
发货至: 中国
ABIN7705443
CTLA4 Protein (AA 37-161) (DYKDDDDK Tag) CTLA4 · Protein 小鼠 Mammalian Cells
  • WB (Western Blotting: 所列应用)
  • ELISA (ELISA: 所列应用)
  • 50 μg
  • 1 mg
  • 10 μg
  • 500 μg
发货至: 中国
ABIN6573318
CTLA4 Protein (AA 36-161) (GST tag) CTLA4 · Protein 人 人细胞
  • 50 μg
  • 1 mg
  • 10 μg
  • 500 μg
发货至: 中国
ABIN7705435
CTLA4 Protein (AA 37-161) (His tag) CTLA4 · Protein 小鼠 Mammalian Cells
  • WB (Western Blotting: 所列应用)
  • ELISA (ELISA: 所列应用)
  • 50 μg
  • 1 mg
  • 10 μg
  • 500 μg
发货至: 中国
ABIN6253377
CTLA4 Protein (AA 1-160, Extracellular Domain, N-Term) (Fc Tag) CTLA4 · Protein 小鼠 NS1 Cells
  • 100 μg
  • 500 μg
  • 992 g
  • 997 g
发货至: 中国
ABIN7888534
CTLA4 Protein (AA 36-161) (mFc Tag) CTLA4 · Protein 人 人细胞
  • 10 μg
发货至: 中国
Protein
  • SDS (SDS-PAGE: 有验证图片)
  • ELISA (ELISA: 有验证图片)
宿主
小鼠
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>90 % as determined by SDS-PAGE.
生物活性
Active
产品编号 ABIN6973042
200 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • Imm (Immunogen: 所列应用)
  • AcA (Activity Assay: 所列应用)
宿主
小鼠
宿主
Mammalian Cells
蛋白类型
Recombinant
纯度
>90 % as determined by SDS-PAGE.
生物活性
Active
产品编号 ABIN7678665
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
人
宿主
CHO Cells
蛋白类型
Recombinant
纯度
>98 % (SDS-PAGE)
生物活性
Active
产品编号 ABIN6253373
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
人
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % (SDS-PAGE)
生物活性
Active
产品编号 ABIN7566054
Protein
宿主
小鼠
宿主
NS1 Cells
蛋白类型
Recombinant
纯度
>98 % (SDS-PAGE)
生物活性
Active
产品编号 ABIN6253376
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
人
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % (SDS-PAGE)
生物活性
Active
产品编号 ABIN7566055
Protein
宿主
人
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % , as determined by SDS-PAGE and HPLC
产品编号 ABIN7865809
Protein
  • SDS (SDS-PAGE: 所列应用)
  • AcA (Activity Assay: 所列应用)
宿主
人
宿主
Baculovirus infected Insect Cells
蛋白类型
Recombinant
纯度
> 95 %
生物活性
Active
产品编号 ABIN7677079
Protein
  • SDS (SDS-PAGE: 所列应用)
  • AcA (Activity Assay: 所列应用)
宿主
人
宿主
Baculovirus infected Insect Cells
蛋白类型
Recombinant
纯度
> 90 %
生物活性
Active
产品编号 ABIN7677098
Protein
  • WB (Western Blotting: 所列应用)
  • ELISA (ELISA: 所列应用)
宿主
小鼠
宿主
Mammalian Cells
蛋白类型
Recombinant
纯度
Greater than 95 % as determined by SDS-PAGE.
产品编号 ABIN7705450
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • SDS (SDS-PAGE: 所列应用)
  • AcA (Activity Assay: 所列应用)
宿主
小鼠
宿主
Baculovirus infected Insect Cells
蛋白类型
Recombinant
纯度
> 90 % by SDS - PAGE
生物活性
Active
产品编号 ABIN7677665
Protein
宿主
豚鼠
宿主
Yeast (Pichia pastoris)
蛋白类型
Recombinant
纯度
> 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN6573161
Protein
宿主
人
宿主
人细胞
蛋白类型
Recombinant
纯度
> 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN4372067
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
人
宿主
人细胞
蛋白类型
Recombinant
纯度
> 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN6573777
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
人
宿主
人细胞
蛋白类型
Recombinant
纯度
> 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN2115489
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • WB (Western Blotting: 所列应用)
  • ELISA (ELISA: 所列应用)
宿主
小鼠
宿主
Mammalian Cells
蛋白类型
Recombinant
纯度
Greater than 95 % as determined by SDS-PAGE.
产品编号 ABIN7705443
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
人
宿主
人细胞
蛋白类型
Recombinant
纯度
> 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN6573318
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • WB (Western Blotting: 所列应用)
  • ELISA (ELISA: 所列应用)
宿主
小鼠
宿主
Mammalian Cells
蛋白类型
Recombinant
纯度
Greater than 95 % as determined by SDS-PAGE.
产品编号 ABIN7705435
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
小鼠
宿主
NS1 Cells
蛋白类型
Recombinant
纯度
>98 % (SDS-PAGE)
生物活性
Active
产品编号 ABIN6253377
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
人
宿主
人细胞
蛋白类型
Recombinant
产品编号 ABIN7888534

Latest Publications for our CTLA4 蛋白

Bai, Gao, Hu, Liu, Li, Dong, Huang, Zhu, Zhou, Li, Shao: "Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth." in: Molecular therapy oncolytics, Vol. 17, pp. 9-20, (2020) (PubMed).

Simons, Lim, Carter, Wagner, Wayham, Adler, Johnson: "Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR." in: mAbs, Vol. 12, Issue 1, pp. 1803646, (2020) (PubMed).

Okada, Kajiya, Omata, Matsumoto, Sato, Kobayashi, Nakamura, Kaneko, Nakamura, Koyama, Sudo, Shin, Okamoto, Watanabe, Tachibana, Hirose, Saito, Takai, Matsumoto, Nakamura, Okabe, Miyamoto, Tanaka: "CTLA4-Ig Directly Inhibits Osteoclastogenesis by Interfering With Intracellular Calcium Oscillations in Bone Marrow Macrophages." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, (2019) (PubMed).

Ganesan, Moon, Barakat: "Revealing the atomistic details behind the binding of B7-1 to CD28 and CTLA-4: A comprehensive protein-protein modelling study." in: Biochimica et biophysica acta. General subjects, Vol. 1862, Issue 12, pp. 2764-2778, (2019) (PubMed).

Galstyan, Markman, Shatalova, Chiechi, Korman, Patil, Klymyshyn, Tourtellotte, Israel, Braubach, Ljubimov, Mashouf, Ramesh, Grodzinski, Penichet, Black, Holler, Sun, Ding, Ljubimov, Ljubimova: "Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy." in: Nature communications, Vol. 10, Issue 1, pp. 3850, (2019) (PubMed).

Gonzalez-Nieto, Castro, Bischof, Shin, Ricciardi, Bailey, Dang, Pedreño-Lopez, Magnani, Ejima, Allison, Gil, Evans, Rakasz, Lifson, Desrosiers, Martins: "Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques." in: PLoS pathogens, Vol. 15, Issue 9, pp. e1008015, (2019) (PubMed).

Ganesan, Ahmed, Okoye, Arutyunova, Babu, Turnbull, Kundu, Shields, Agopsowicz, Xu, Tabana, Srivastava, Zhang, Moon, Belovodskiy, Hena, Kandadai, Hosseini, Hitt, Walker, Smylie, West, Siraki, Lemieux et al.: "Comprehensive in vitro characterization of PD-L1 small molecule inhibitors. ..." in: Scientific reports, Vol. 9, Issue 1, pp. 12392, (2019) (PubMed).

Zhao, Lee, Lin, Gassen, Xu, Huang, Xiao, Bonorino, Lu, Bui, Hui: "PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways." in: Immunity, Vol. 51, Issue 6, pp. 1059-1073.e9, (2019) (PubMed).

Waight, Chand, Dietrich, Gombos, Horn, Gonzalez, Manrique, Swiech, Morin, Brittsan, Tanne, Akpeng, Croker, Buell, Stein, Savitsky, Wilson: "Selective FcγR Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens." in: Cancer cell, Vol. 33, Issue 6, pp. 1033-1047.e5, (2019) (PubMed).

Ljungars, Svensson, Carlsson, Birgersson, Tornberg, Frendéus, Ohlin, Mattsson: "Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes." in: Frontiers in pharmacology, Vol. 10, pp. 847, (2019) (PubMed).

Aliases for CTLA4 蛋白

cytotoxic T-lymphocyte associated protein 4 (CTLA4) 蛋白
cytotoxic T-lymphocyte-associated protein 4 (Ctla4) 蛋白
CD 蛋白
CD152 蛋白
Cd152 蛋白
CELIAC3 蛋白
CTLA-4 蛋白
Ctla-4 蛋白
CTLA4 蛋白
GRD4 蛋白
GSE 蛋白
IDDM12 蛋白
Ly-56 蛋白
sCTLA4 蛋白
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