CD19 Protein (AA 20-291) (His tag,FITC)
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- 抗原 See all CD19 蛋白
- CD19 (CD19 Molecule (CD19))
- 蛋白类型
- Recombinant
- 产品特性
- AA 20-291
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This CD19 protein is labelled with His tag,FITC.
- 原理
- FITC-Compatible Human CD19 Protein
- 序列
- Pro20-Lys291
- 产品特性
- FITC-Compatible Human CD19 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Pro20-Lys291.
- 纯度
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- 过滤
- 0.22 μm filtered
- 内毒素水平
- Less than 1EU per μg by the LAL method.
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Supplied as 0.22 μm filtered solution in PBS ( pH 7.4).
- 储存条件
- -80 °C
- 储存方法
- Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- CD19 (CD19 Molecule (CD19))
- 别名
- CD19 (CD19 产品)
- 别名
- B4 Protein, CVID3 Protein, AW495831 Protein, CD19 Protein, CD19 molecule Protein, CD19 antigen Protein, CD19 Protein, Cd19 Protein
- 背景
- CD19 is a B-lineage-specific transmembrane glycoprotein, the expression of which is maintained on more than 95 % B-cell malignancies. This strict lineage restriction makes CD19 an ideal target for immune therapies using chimeric antigen receptors (CARs). T cells engineered to express a chimeric antigen receptor (CAR) against CD19 have recently been FDA approved for the treatment of relapsed or refractory large B-cell lymphoma. Despite the success and curative potential of CD19 CAR T cells, several reports describing disease relapse due to antigen loss are now emerging.
- 分子量
- 60.1 kDa. Due to glycosylation, the protein migrates to 68-72 kDa based on Tris-Bis PAGE result.
- 途径
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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