CD19 Protein (AA 20-291) (Fc Tag)
(2 references)-
- 抗原 See all CD19 蛋白
- CD19 (CD19 Molecule (CD19))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 20-291
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This CD19 protein is labelled with Fc Tag.
- 序列
- AA 20-291
- 产品特性
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 56.3 kDa. The protein migrates as 56-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- 纯度
- >95 % as determined by SDS-PAGE.
- 过滤
- 0.22 μm filtered
- 内毒素水平
- Less than 0.1 EU per μg by the LAL method.
- Top Product
- Discover our top product CD19 蛋白
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CD19 Molecule (CD19) (AA 20-291) protein (His tag,FITC)
CD19 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD19 Molecule (CD19) (AA 20-291) (Active) protein (His tag)CD19 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by reduced SDS-PAGE. Active
CD19 Molecule (CD19) (AA 20-291) (Active) protein (Fc Tag,Biotin)CD19 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
CD19 Molecule (CD19) (AA 21-291) protein (His tag)CD19 宿主: 猕猴, Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD19 Molecule (CD19) (AA 20-291) protein (His tag)CD19 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
CD19 Molecule (CD19) (AA 20-291) (Active) protein (His tag,AVI tag,Biotin)CD19 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
CD19 Molecule (CD19) (AA 19-287) protein (His tag)CD19 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Tris-Bis PAGE
CD19 Molecule (CD19) protein (Fc-His Tag)CD19 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
CD19 Molecule (CD19) (AA 1-556) protein (GST tag)CD19 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
CD19 Molecule (CD19) (AA 98-187) protein (GST tag)CD19 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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: "Prolonged PD1 Expression on Neonatal Vδ2 Lymphocytes Dampens Proinflammatory Responses: Role of Epigenetic Regulation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 5, pp. 1884-92, (2017) (PubMed).
: "A CD19/Fc fusion protein for detection of anti-CD19 chimeric antigen receptors." in: Journal of translational medicine, Vol. 11, pp. 23, (2013) (PubMed).
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: "Prolonged PD1 Expression on Neonatal Vδ2 Lymphocytes Dampens Proinflammatory Responses: Role of Epigenetic Regulation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 5, pp. 1884-92, (2017) (PubMed).
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- 抗原
- CD19 (CD19 Molecule (CD19))
- 别名
- CD19 (CD19 产品)
- 别名
- B4 Protein, CVID3 Protein, AW495831 Protein, CD19 Protein, CD19 molecule Protein, CD19 antigen Protein, CD19 Protein, Cd19 Protein
- 背景
- B-lymphocyte antigen CD19 is also known as CD19 (Cluster of Differentiation 19), is a single-pass type I membrane protein which contains two Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. It primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. As on T cells, several surface molecules form the antigen receptor and form a complex on B lymphocytes. The (almost) B cell-specific CD19 phosphoglycoprotein is one of these molecules. The others are CD21 and CD81. These surface immunoglobulin (sIg)-associated molecules facilitate signal transduction. On living B cells, anti-immunoglobulin antibody mimicking exogenous antigen causes CD19 to bind to sIg and internalize with it. The reverse process has not been demonstrated, suggesting that formation of this receptor complex is antigen-induced. This molecular association has been confirmed by chemical studies. Mutations in CD19 are associated with severe immunodeficiency syndromes characterized by diminished antibody production. CD19 has been shown to interact with: CD81, CD82, Complement receptor 2, and VAV2.
- 分子量
- 56.3 kDa
- NCBI登录号
- NP_001761
- 途径
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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