VEGFR2/CD309 Protein (Fc Tag)
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- 抗原 See all VEGFR2/CD309 (VEGFR2) 蛋白
- VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This VEGFR2/CD309 protein is labelled with Fc Tag.
- 原理
- Recombinant Mouse VEGFR2/Flk-1/KDR Protein (Fc Tag)(Active)
- 序列
- Met1-Glu762
- 产品特性
- A DNA sequence encoding the mouse KDR (P35918) (Met1-Glu762) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
- 纯度
- > 90 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Immobilized mouse VEGF164 at 10 μg/ml (100 μl/well) can bind mouse KDR-Fc, The EC50 of mouse KDR-Fc is 0.11-0.27 μg/ml.
- Top Product
- Discover our top product VEGFR2 蛋白
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VEGF Receptor 2 (VEGFR2) (AA 20-764) protein (His-Avi Tag,Biotin)
VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
VEGF Receptor 2 (VEGFR2) (AA 20-764) protein (His-Avi Tag)VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
VEGF Receptor 2 (VEGFR2) protein (mFc Tag)VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
VEGF Receptor 2 (VEGFR2) (AA 20-764) protein (His tag)VEGFR2 宿主: 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
VEGF Receptor 2 (VEGFR2) (AA 20-764) protein (mFc Tag,Biotin)VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
VEGF Receptor 2 (VEGFR2) (AA 20-764) (Active) protein (His tag)HPLC verified VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
VEGF Receptor 2 (VEGFR2) (AA 20-762) protein (His tag)VEGFR2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
VEGF Receptor 2 (VEGFR2) (AA 807-1356) (Active) protein (GST tag)VEGFR2 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
VEGF Receptor 2 (VEGFR2) (AA 20-762) (Active) protein (Fc Tag)VEGFR2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
VEGF Receptor 2 (VEGFR2) (AA 20-764) (Active) protein (His tag,AVI tag,Biotin)VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))
- 别名
- VEGFR2/Flk-1/KDR (VEGFR2 产品)
- 别名
- CD309 Protein, FLK1 Protein, VEGFR Protein, VEGFR2 Protein, 6130401C07 Protein, Flk-1 Protein, Flk1 Protein, Krd-1 Protein, Ly73 Protein, VEGFR-2 Protein, sVEGFR-2 Protein, Vegfr-2 Protein, FLK-1 Protein, flk-1 Protein, vegfr-2 Protein, KDR Protein, FLK/KDR Protein, flk1 Protein, flk1b Protein, kdrb Protein, si:busm1-205d10.1 Protein, si:ch211-254j6.1 Protein, si:ch211-278f21.4 Protein, wu:fc31a09 Protein, fk52c05 Protein, flk Protein, kdr Protein, kdra Protein, vegfr2 Protein, vegfr4 Protein, vegr2 Protein, wu:fk52c05 Protein, kinase insert domain receptor Protein, kinase insert domain protein receptor Protein, vascular endothelial growth factor receptor kdr-like Protein, kinase insert domain receptor (a type III receptor tyrosine kinase) Protein, kinase insert domain receptor like Protein, KDR Protein, Kdr Protein, LOC100136647 Protein, kdr Protein, kdrl Protein
- 背景
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Background: VEGFR2, also called as KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the inhibition of VEGFR2 activity and its downstream signaling are important targets for the treatment of diseases involving angiogenesis. VEGFR2 transduces the major signals for angiogenesis via its strong tyrosine kinase activity. However, unlike other representative tyrosine kinase receptors, VEGFR2 does not use the Ras pathway as a major downstream signaling but rather uses the phospholipase C-protein kinase C pathway to signal mitogen-activated protein (MAP)-kinase activation and DNA synthesis. VEGFR2 is a direct and major signal transducer for pathological angiogenesis, including cancer and diabetic retinopathy, in cooperation with many other signaling partners; thus, VEGFR2 and its downstream signaling appear to be critical targets for the suppression of these diseases. VEGF and VEGFR2-mediated survival signaling is critical to endothelial cell survival, maintenance of the vasculature and alveolar structure and regeneration of lung tissue. Reduced VEGF and VEGFR2 expression in emphysematous lungs has been linked to increased endothelial cell death and vascular regression.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: 6130401C07;Flk-1;Flk1;Krd-1;Ly73;sVEGFR-2;VEGFR-2;VEGFR2
- 分子量
- 110 kDa
- UniProt
- P35918
- 途径
- RTK signaling, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling
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