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TNFRSF18 Protein (Fc Tag)

TNFRSF18 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
产品编号 ABIN7321198
发货至: 中国
  • 抗原 See all TNFRSF18 蛋白
    TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))
    蛋白类型
    Recombinant
    宿主
    • 20
    • 7
    • 3
    • 2
    • 1
    • 1
    大鼠
    资源
    • 24
    • 3
    • 3
    • 3
    • 1
    HEK-293 Cells
    标记
    This TNFRSF18 protein is labelled with Fc Tag.
    原理
    Recombinant Rat GITR/TNFRSF18 Protein (Fc Tag)
    序列
    Met1-Lys121
    产品特性
    A DNA sequence encoding the rat TNFRSF18 (Q5M835) (Met1-Lys121) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
    纯度
    > 95 % as determined by SDS-PAGE
    内毒素水平
    < 1.0 EU per μg of the protein as determined by the LAL method
    Top Product
    Discover our top product TNFRSF18 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile PBS, pH 7.4
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))
    别名
    GITR/TNFRSF18 (TNFRSF18 产品)
    别名
    GITR Protein, TNFRSF18 Protein, AITR Protein, Gitr Protein, CD357 Protein, GITR-D Protein, TNF receptor superfamily member 18 Protein, tumor necrosis factor receptor superfamily, member 18 Protein, TNFRSF18 Protein, Tnfrsf18 Protein
    背景

    Background: GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.Immune CheckpointImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    Synonym: TNFRSF18

    分子量
    37.7 kDa
    UniProt
    Q5M835
    途径
    Cancer Immune Checkpoints
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