SOCS3 Protein (TRX tag,His tag)
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- 抗原 See all SOCS3 蛋白
- SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This SOCS3 protein is labelled with TRX tag,His tag.
- 原理
- Recombinant Human SOCS3/CIS3 Protein (His & Trx Tag)
- 序列
- Met 1-Leu 225
- 产品特性
- A DNA sequence encoding the human SOCS3 (O14543) (Met 1-Leu 225) was fused with a Trx and a polyhistide tag at the N-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product SOCS3 蛋白
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Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225) protein (GST tag)
SOCS3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225) protein (His-IF2DI Tag)SOCS3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225) (Active) protein (His tag)SOCS3 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） > 97 % AcA, CC Active
Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225), (full length) protein (His tag)SOCS3 宿主: 大鼠 宿主: 酵母菌 Recombinant > 90 % SDS
Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225), (full length) protein (His-SUMO Tag)SOCS3 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 50 mM Tris, pH 8.0
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))
- 别名
- SOCS3/CIS3 (SOCS3 产品)
- 别名
- socs3 Protein, fj09e12 Protein, zgc:56537 Protein, wu:fj09e12 Protein, MGC64393 Protein, MGC75749 Protein, xsocs3 Protein, MGC81248 Protein, atod4 Protein, cis3 Protein, cish3 Protein, socs-3 Protein, ssi-3 Protein, ssi3 Protein, SOCS3 Protein, ATOD4 Protein, CIS3 Protein, Cish3 Protein, SOCS-3 Protein, SSI-3 Protein, SSI3 Protein, Cis3 Protein, EF-10 Protein, Ef10 Protein, Ssi3 Protein, Socs-3 Protein, Ssi-3 Protein, suppressor of cytokine signaling 3a Protein, suppressor of cytokine signaling 3 S homeolog Protein, suppressor of cytokine signaling 3 Protein, suppressor of cytokine signaling 3 L homeolog Protein, socs3a Protein, socs3.S Protein, socs3 Protein, socs3.L Protein, SOCS3 Protein, Socs3 Protein
- 背景
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Background: Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. SOCS3 / CIS3 contains one SH2 domain and one SOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 / CIS3 is involved in negative regulation of cytokines that signal through the JAK / STAT pathway. SOCS3 / CIS3 inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. SOCS3 / CIS3 suppresses fetal liver erythropoiesis. It regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. SOCS3 / CIS3 regulates IL-6 signaling. SOCS3 / CIS3 interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. SOCS3 / CIS3 could be used as a possible therapeutic agent for treating rheumatoid arthritis.
Synonym: ATOD4;CIS3;Cish3;SOCS-3;SSI-3;SSI3
- 分子量
- 41.9 kDa
- UniProt
- O14543
- 途径
- JAK/STAT Signaling, Response to Growth Hormone Stimulus, Hepatitis C
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