STAT1 Protein (GST tag,His tag)
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- 抗原 See all STAT1 蛋白
- STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This STAT1 protein is labelled with GST tag,His tag.
- 原理
- Recombinant Human STAT1 Protein (His &GST Tag)
- 序列
- Met 1-Val 712
- 产品特性
- A DNA sequence encoding the human STAT1 isoform beta (P42224-2) (Met 1-Val 712) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 纯度
- > 92 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (AA 1-712) protein (His tag)
STAT1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % by SDS - PAGE SDS
Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (AA 1-712) protein (GST tag)STAT1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (AA 613-712) protein (GST tag)STAT1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (AA 2-750) protein (His tag)Crystallography grade STAT1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (AA 2-749) protein (His tag)Crystallography grade STAT1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))
- 别名
- STAT1 (STAT1 产品)
- 别名
- CANDF7 Protein, ISGF-3 Protein, STAT91 Protein, 2010005J02Rik Protein, AA408197 Protein, XStat1 Protein, STAT4 Protein, DD6G4-4 Protein, STAT Protein, STAT1 Protein, dZ182H3.3 Protein, si:by134g18.2 Protein, si:by51f19.1 Protein, si:dz182h3.3 Protein, si:dz199m19.1 Protein, si:dz73o4.2 Protein, stat1 Protein, signal transducer and activator of transcription 1 Protein, signal transducer and activator of transcription 1 L homeolog Protein, signal transducer and activator of transcription 1, 91kDa Protein, signal transducer and activator of transcription 4 Protein, signal transducer and activator of transcription 1a Protein, STAT1 Protein, Stat1 Protein, stat1.L Protein, stat4 Protein, stat1a Protein
- 背景
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Background: STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by various ligands, including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. It is a signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and growth factors. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 becomes activated in response to KITLG/SCF and KIT signaling and may mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Defects in STAT1 can cause STAT1 deficiency complete and familial candidiasis type 7.
Synonym: Signal Transducer and Activator of Transcription 1-Alpha/Beta, Transcription Factor ISGF-3 Components p91/p84, STAT1, CANDF7,IMD31A,IMD31B,IMD31C,ISGF-3,STAT91
- 分子量
- 111 kDa
- 途径
- JAK/STAT Signaling, RTK signaling, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events
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