SFRP2 Protein (His tag)
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- 抗原 See all SFRP2 蛋白
- SFRP2 (Secreted Frizzled-Related Protein 2 (SFRP2))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This SFRP2 protein is labelled with His tag.
- 原理
- Recombinant Mouse sFRP2 Protein (His Tag)
- 序列
- Met 1-Cys 295
- 产品特性
- A DNA sequence encoding the mouse sFRP2 (NP_033170.1) (Met 1-Cys 295) was expressed with a C-terminal polyhistidine tag.
- 纯度
- > 95 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product SFRP2 蛋白
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Secreted Frizzled-Related Protein 2 (SFRP2) (AA 25-295) protein (His tag)
SFRP2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Secreted Frizzled-Related Protein 2 (SFRP2) (AA 25-295) protein (His tag)SFRP2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Secreted Frizzled-Related Protein 2 (SFRP2) (AA 25-171) protein (His-IF2DI Tag)SFRP2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Secreted Frizzled-Related Protein 2 (SFRP2) (AA 25-295) protein (His tag)Crystallography grade SFRP2 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Secreted Frizzled-Related Protein 2 (SFRP2) (AA 25-295) protein (His tag)Crystallography grade SFRP2 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Secreted Frizzled-Related Protein 2 (SFRP2) protein (GST tag,His tag)SFRP2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Secreted Frizzled-Related Protein 2 (SFRP2) (AA 20-295) protein (His tag)SFRP2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 85 % by SDS - PAGE SDS
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- SFRP2 (Secreted Frizzled-Related Protein 2 (SFRP2))
- 别名
- sFRP2 (SFRP2 产品)
- 别名
- frp-2 Protein, sarp1 Protein, sdf-5 Protein, sfrp-2 Protein, SFRP2 Protein, sfrp2 Protein, FRP-2 Protein, SARP1 Protein, SDF-5 Protein, AI851596 Protein, Sdf5 Protein, hm:zeh0225 Protein, zeh0225 Protein, zgc:153618 Protein, SFRP-2 Protein, secreted frizzled-related protein 2 Protein, secreted frizzled related protein 2 Protein, secreted frizzled-related protein 2 S homeolog Protein, secreted frizzled-related protein Protein, sfrp2 Protein, sfrp2 Protein, SFRP2 Protein, sfrp2.S Protein, LOAG_01461 Protein, Sfrp2 Protein
- 背景
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Background: The Secreted frizzled-related protein (SFRP) family consists of five secreted glycoproteins in humans (SFRP1~5) that act as extracellular signaling ligands. Each SFRP is approximately 300 amino acids in length and contains a cysteine-rich domain (CRD) that shares 30-50% sequence homology with the CRD of Frizzled (Fz) receptors, a putative signal sequence, and a conserved hydrophilic carboxy-terminal domain. SFRPs are able to bind Wnt proteins and Fz receptors in the extracellular compartment. The interaction between SFRPs and Wnt proteins prevents the latter from binding the Fz receptors. The Wnt pathway plays a key role in embryonic development, cell differentiation and cell proliferation. sFRP2 is a member of the SFRP family acting as soluble modulators of Wnt signaling and contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins called FZ domain and a NTR domain.sFRP2 inhibites hypoxia induced endothelial cell apoptosis and increases endothelial cell migration. It prevents mesoderm specification and maintains the cells in the undifferentiated state. SFRP2 is also a novel stimulator of angiogenesis that stimulates angiogenesis via a calcineurin/NFAT pathway, thus is regarded as a favorable target for the inhibition of angiogenesis in solid tumors. Mouse sFRP2 is highly expressed in the eye and is also detected in heart and lung at low level.
Synonym: AI851596;Sdf5
- 分子量
- 32.5 kDa
- NCBI登录号
- NP_033170
- 途径
- WNT signaling, Tube Formation, Positive Regulation of Endopeptidase Activity, Negative Regulation of intrinsic apoptotic Signaling, Positive Regulation of fat Cell Differentiation
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