RRM2B Protein (His tag)
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- 抗原 See all RRM2B 蛋白
- RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This RRM2B protein is labelled with His tag.
- 原理
- Recombinant Human RRM2B/P53R2 Protein (His Tag)
- 序列
- Met 1-Phe 351
- 产品特性
- A DNA sequence encoding the human RRM2B (Q7LG56-1) (Met 1-Phe 351) was expressed, with a polyhistide tag at the N-terminus.
- 纯度
- > 92 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product RRM2B 蛋白
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Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B) (AA 3-84) protein (GST tag)
RRM2B 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B) protein (Myc-DYKDDDDK Tag)RRM2B 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, 30 % glycerol, pH 8.5
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))
- 别名
- RRM2B/P53R2 (RRM2B 产品)
- 别名
- p53r2 Protein, RRM2B Protein, MTDPS8A Protein, MTDPS8B Protein, P53R2 Protein, p53R2 Protein, ribonucleotide reductase M2 B (TP53 inducible) S homeolog Protein, ribonucleotide reductase regulatory TP53 inducible subunit M2B Protein, ribonucleotide reductase M2 B (TP53 inducible) Protein, rrm2b.S Protein, RRM2B Protein, rrm2b Protein, Rrm2b Protein
- 背景
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Background: Ribonucleoside reductase subunit M2B, also known as RRM2B or p53R2, is an enzyme belonging to the iron-dependent ribonucleotide reductase (RNR) enzyme family which is essential for DNA synthesis. Ribonucleotide reductase (RNR) is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides and plays a critical role in regulating the total rate of DNA synthesis so that DNA to cell mass is maintained at a constant ratio during cell division and DNA repair. RRM2B is a phosphorylated protein. It is hypothesized that RRM2B activity can be regulated at the posttranslational level in response to DNA damage. RRM2B has previously been shown to be essential for the maintenance of mtDNA copy number and its candidacy for tumor suppression has been evaluated in several mutational analyses of different cancer types. However, the contribution of RRM2B to the DNA damage response has been questioned because its transcriptional induction upon DNA damage is not rapid enough for prompt DNA repair. Instead, ATM-mediated phosphorylation has been suggested to regulate the DNA repair activity of RRM2B posttranslationally. In addition, a defect in RRM2B can induce a mild muscle disease of adult onset through disturbance of mitochondrial homeostasis but that this defect does not appear to be oncogenic.
Synonym: MTDPS8A;MTDPS8B;P53R2
- 分子量
- 42.6 kDa
- 途径
- p53 Pathway, Negative Regulation of intrinsic apoptotic Signaling
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