PTPN1 Protein (His tag)
-
- 抗原 See all PTPN1 蛋白
- PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
-
宿主
- 人
-
资源
- 大肠杆菌（E. Coli）
- 标记
- This PTPN1 protein is labelled with His tag.
- 原理
- Recombinant Human PTP1B/PTPN1 Protein (His Tag)(Active)
- 序列
- Glu 2-Asn 321
- 产品特性
- A DNA sequence encoding the human PTPN1 (NP_002818.1) (Glu 2-Asn 321) was expressed, with a polyhistide tag at the N-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Biological Activity Comment
- Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor (aa988-998) phosphopeptide substrate, R&D Systems, Catalog # ES006.The specific activity is > 15 nmoles/min/μg.
- Top Product
- Discover our top product PTPN1 蛋白
-
Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 268-406) protein (His tag)
PTPN1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 1-321) (Active) proteinPTPN1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant SDS, Func Active
Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 1-435) protein (GST tag)PTPN1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 322-406) protein (GST tag)PTPN1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 1-435) protein (Strep Tag)Crystallography grade PTPN1 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 1-432) protein (Strep Tag)Crystallography grade PTPN1 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) protein (DYKDDDDK Tag)PTPN1 宿主: 人 宿主: Insect cells (Sf9) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) protein (Myc-DYKDDDDK Tag)PTPN1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
- 限制
- 仅限研究用
-
- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 10 mM Hepes, 150 mM NaCl, 1 mM DTT, pH 7.5
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
-
- 抗原
- PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))
- 别名
- PTP1B/PTPN1 (PTPN1 产品)
- 别名
- PTPN1 Protein, PTP1B Protein, PTP-1B Protein, PTP-HA2 Protein, Ptp Protein, ptp1b Protein, wu:fk54h03 Protein, CPTP1 Protein, protein tyrosine phosphatase, non-receptor type 1 Protein, protein tyrosine phosphatase, non-receptor type 1 L homeolog Protein, PTPN1 Protein, Ptpn1 Protein, ptpn1 Protein, ptpn1.L Protein
- 背景
-
Background: PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein phosphatase domain and is expressed in many tissues. PTP1B is localized to the cytoplasmic face of the endoplasmic reticulum. PTP1B was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of PTP1B in cell growth control, and cell response to IFN stimulation.
Synonym: PTP1B,PTPN1
- 分子量
- 38 kDa
- NCBI登录号
- NP_002818
- 途径
- TLR signaling, Response to Growth Hormone Stimulus, ER-Nucleus Signaling, Platelet-derived growth Factor Receptor Signaling
-
