PDGFRA Protein (GST tag,His tag)
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- 抗原 See all PDGFRA 蛋白
- PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This PDGFRA protein is labelled with GST tag,His tag.
- 原理
- Recombinant Human PDGFRa/CD140a Protein (His & GST Tag)(Active)
- 序列
- Gln551-Leu1089
- 产品特性
- A DNA sequence encoding the human PDGFRA (P16234-1) (Gln551-Leu1089) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- The specific activity was determined to be 8 nmol/min/mg using MBP as substrate.
- Top Product
- Discover our top product PDGFRA 蛋白
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Platelet Derived Growth Factor Receptor alpha (PDGFRA) protein (His-Avi Tag)
PDGFRA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 24-524) protein (His tag)PDGFRA 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Platelet Derived Growth Factor Receptor alpha (PDGFRA) protein (His-Avi Tag,Biotin)PDGFRA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Platelet Derived Growth Factor Receptor alpha (PDGFRA) (Asp842Val-Mutant) (Active) protein (GST tag)PDGFRA 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Platelet Derived Growth Factor Receptor alpha (PDGFRA) (Thr674Ile-Mutant) (Active) protein (GST tag)PDGFRA 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Platelet Derived Growth Factor Receptor alpha (PDGFRA) (Val561Asp-Mutant) (Active) protein (GST tag)PDGFRA 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 551-1089) (Active) protein (GST tag)PDGFRA 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
Platelet Derived Growth Factor Receptor alpha (PDGFRA) protein (Fc Tag)PDGFRA 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 24-524) protein (His tag)PDGFRA 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 25-218) protein (GST tag)PDGFRA 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol, 3 mM DTT
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))
- 别名
- PDGFRa/CD140a (PDGFRA 产品)
- 别名
- AI115593 Protein, CD140a Protein, Pdgfr-2 Protein, APDGFR Protein, PDGFACE Protein, CD140A Protein, PDGFR-2 Protein, PDGFR2 Protein, RHEPDGFRA Protein, PDGFR Protein, PDGFR-A Protein, platelet derived growth factor receptor alpha Protein, platelet derived growth factor receptor, alpha polypeptide Protein, platelet-derived growth factor receptor, alpha polypeptide L homeolog Protein, platelet-derived growth factor receptor, alpha polypeptide Protein, PDGFRA Protein, Pdgfra Protein, pdgfra.L Protein
- 背景
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Background: PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfamily of receptor tyrosine kinase (RTKs) with the similar structure characteristics of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGFRA is expressed in oligodendrocyte progenitor cells and mesothelial cell, and binds all three ligand isoforms PDGF-AA, PDGF-BB and PDGF-AB with high affinity, whereas PDGFRB dose not bind PDGF-AA. PDGFRA plays an essential role in regulating proliferation, chemotaxis and migration of mesangial cells. Recent studies have indicated that PDGFRA acts as a critical mediator of signaling in testis organogenesis and Leydig cell differentiation, and in addition, particularly important for kidney development. Additionally, PDGFRA is involved in tumor angiogenesis and maintenance of the tumor microenvironment and has been implicated in development and metastasis of Hepatocellular carcinoma (HCC). PDGFRA may represent a potential therapeutic target in thymic tumours. PDGFRA gene amplification rather than gene mutation may be the underlying genetic mechanism driving PDGFRA overexpression in a portion of gliomas.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: CD140A;PDGFR-2;PDGFR2;RHEPDGFRA;Platelet-derived growth factor receptor alpha; PDGFR-alpha; Alpha platelet-derived growth factor receptor;CD140 antigen-like family member A; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 2
- 分子量
- 89.2 kDa
- 途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Platelet-derived growth Factor Receptor Signaling
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