NTRK3 Protein (His tag)
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- 抗原 See all NTRK3 蛋白
- NTRK3 (Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This NTRK3 protein is labelled with His tag.
- 原理
- Recombinant Mouse TrkC/NTRK3 Protein (His Tag)(Active)
- 序列
- Met 1-Thr 429
- 产品特性
- A DNA sequence encoding the extracellular domain of mouse TrkC (NP_032772.3) (Met 1-Thr 429) was expressed, with a C-terminal polyhistidine tag.
- 纯度
- > 95 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Immobilized mouse NTRK3-His at 10 μg/ml (100 μl/well) can bind biotinylated human NT3, The EC50 of biotinylated human NT3 is 0.04-0.08 μg/ml.
- Top Product
- Discover our top product NTRK3 蛋白
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Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3) (AA 456-825) (Active) protein (GST tag)
NTRK3 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3) (AA 510-825) (Active) protein (His-GST)NTRK3 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3) (AA 41-160) protein (GST tag)NTRK3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3) protein (His tag)NTRK3 宿主: 小鼠 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- NTRK3 (Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3))
- 别名
- TrkC/NTRK3 (NTRK3 产品)
- 别名
- TRKC Protein, gp145(trkC) Protein, trkC Protein, AW125844 Protein, Ntrk3_tv3 Protein, TrkC Protein, neurotrophic receptor tyrosine kinase 3 Protein, neurotrophic tyrosine kinase, receptor, type 3 Protein, NTRK3 Protein, Ntrk3 Protein
- 背景
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Background: NT-3 growth factor receptor also known as neurotrophic tyrosine kinase receptor type 3 or TrkC tyrosine kinase or Trk-C receptor, is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkC/NTRK3 is widely expressed in the developing and adult nervous system. In later embryonic development, TrkC/NTRK3 is expressed in various structures of the CNS including the caudatoputamen, septal nuclei, cerebellum, and brainstem. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. In the PNS, trkC hybridization appears to correlate, both temporally and spatially, with the outgrowth of axons toward their peripheral targets. TrkC/NTRK3 is widely expressed in the three identified branches of the mammalian nervous system and appears to correlate with the expression of NT-3, its cognate ligand. The apparent colocalization of trkC transcripts with NT-3 raises the possibility this neurotrophin exerts its trophic effects by a paracrine and/or autocrine mechanism. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in TrkC encoding gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: GP145-TrkB/GP95-TrkB;Tkrb;trk-B;trkB
- 分子量
- 46.1 kDa
- NCBI登录号
- NP_032772
- 途径
- RTK signaling, Neurotrophin Signaling Pathway, Regulation of Cell Size
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