MICB Protein (His tag,Fc Tag)
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- 抗原 See all MICB 蛋白
- MICB (MHC Class I Polypeptide-Related Sequence B (MICB))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This MICB protein is labelled with His tag,Fc Tag.
- 原理
- Recombinant Human MICB Protein (His & Fc Tag)(Active)
- 序列
- Met 1-Gly 298
- 产品特性
- A DNA sequence encoding the extracellular domain of human MICB (NP_005922.2) (Met 1-Gly 298) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
- 纯度
- > 98 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Immobilized human His-NKG2D (78-216) at 10 μg/ml (100 μl/well) can bind human MICB-Fch, The EC50 of human MICB-Fch is 15.9-37.1 ng/ml.
- Top Product
- Discover our top product MICB 蛋白
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MHC Class I Polypeptide-Related Sequence B (MICB) (AA 23-298) protein (His-Avi Tag)
MICB 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
MHC Class I Polypeptide-Related Sequence B (MICB) protein (His-Avi Tag,Biotin)MICB 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
MHC Class I Polypeptide-Related Sequence B (MICB) protein (His tag)MICB 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
MHC Class I Polypeptide-Related Sequence B (MICB) (AA 1-340) protein (GST tag)MICB 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
MHC Class I Polypeptide-Related Sequence B (MICB) (AA 121-220) protein (GST tag)MICB 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
MHC Class I Polypeptide-Related Sequence B (MICB) (AA 23-309) protein (His tag)Crystallography grade MICB 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS, Crys
MHC Class I Polypeptide-Related Sequence B (MICB) (AA 23-383) protein (rho-1D4 tag)Crystallography grade MICB 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- MICB (MHC Class I Polypeptide-Related Sequence B (MICB))
- 别名
- MICB (MICB 产品)
- 别名
- PERB11.2 Protein, MHC class I polypeptide-related sequence B Protein, MHC class I-related protein-like Protein, MICB Protein, LOC512825 Protein
- 背景
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Background: MHC class I polypeptide-related sequence B; also known as MICB; is a heavily glycosylated protein serving as a ligand for the type I I receptor NKG2D. MICB shares 85% amino acid identity with MICA; a closely related protein; both of which contain three extracellular immunoglobulin-like domains; but without capacity to bind peptide or interact with beta-2-microglobulin. acting as a stress-induced self-antigen; binding of MICB to the NKG2D receptor activates the cytolytic response of natural killer (NK) cells; CD8+αβ T cells; and γδ T cells on which the receptor is expressed. MICA/B are minimally expressed on normal cells; but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B recognition thus is involved in tumor surveillance; viral infections; and autoimmune diseases.
Synonym: PERB11.2
- 分子量
- 59.5 kDa
- NCBI登录号
- NP_005922
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