MICB Protein (AA 1-298) (His tag)
-
- 抗原 See all MICB 蛋白
- MICB (MHC Class I Polypeptide-Related Sequence B (MICB))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 1-298
- 宿主
- 人
-
资源
- HEK-293 Cells
- 标记
- This MICB protein is labelled with His tag.
- 序列
- Met 1-Gly 298
- 产品特性
- A DNA sequence encoding the extracellular domain of human MICB (NP_005922.2) (Met 1-Gly 298) was expressed with a C-terminal polyhistidine tag.
- 纯度
- >98 % as determined by reducing SDS-PAGE.
- 内毒素水平
- <1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Immobilized human MICB-His at 10 μg/ml (100 μl/well) can bind human NKG2D, The EC50 of human NKG2D is 0.52-1.2 μg/ml.
- Top Product
- Discover our top product MICB 蛋白
-
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
-
- 抗原
- MICB (MHC Class I Polypeptide-Related Sequence B (MICB))
- 别名
- MICB (MICB 产品)
- 别名
- PERB11.2 Protein, MHC class I polypeptide-related sequence B Protein, MHC class I-related protein-like Protein, MICB Protein, LOC512825 Protein
- 背景
-
Background: MHC class I polypeptide-related sequence B, also known as MICB, is a heavily glycosylated protein serving as a ligand for the type II receptor NKG2D. MICB shares 85 % amino acid identity with MICA, a closely related protein, both of which contain three extracellular immunoglobulin-like domains, but without capacity to bind peptide or interact with beta-2-microglobulin. acting as a stress-induced self-antigen, binding of MICB to the NKG2D receptor activates the cytolytic response of natural killer (NK) cells, CD8+αβ T cells, and γδ T cells on which the receptor is expressed. MICA/B are minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B recognition thus is involved in tumor surveillance, viral infections, and autoimmune diseases.
Synonym: PERB11.2
- 分子量
- 33 kDa
- UniProt
- Q29980
-