LAIR1 Protein (Fc Tag)
-
- 抗原 See all LAIR1 蛋白
- LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))
- 蛋白类型
- Recombinant
-
宿主
- 小鼠
-
资源
- HEK-293 Cells
- 标记
- This LAIR1 protein is labelled with Fc Tag.
- 原理
- Recombinant Mouse LAIR1 Protein (Fc Tag)
- 序列
- Gln22-Ser133
- 产品特性
- A DNA sequence encoding the mouse LAIR1 (Q8BG84-6) (Gln22-Ser133) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
- 纯度
- > 95 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product LAIR1 蛋白
-
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 22-163) protein (His-Avi Tag)
LAIR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 22-163) protein (Fc Tag)LAIR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 22-163) protein (His-Avi Tag,Biotin)LAIR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 22-141) protein (His tag)LAIR1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 22-165) protein (His tag)LAIR1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 22-125), (Extracellular Domain) proteinLAIR1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % by SDS - PAGE SDS
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) protein (His tag)LAIR1 宿主: 猕猴 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) protein (mFc Tag)LAIR1 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 1-287) protein (GST tag)LAIR1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 188-287) protein (GST tag)LAIR1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- 抗原
- LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))
- 别名
- LAIR1 (LAIR1 产品)
- 别名
- 5133400O11Rik Protein, BB115266 Protein, D7Bwg0421e Protein, Lair-1 Protein, mLair-1 Protein, CD305 Protein, LAIR-1 Protein, leukocyte-associated Ig-like receptor 1 Protein, leukocyte associated immunoglobulin like receptor 1 Protein, leukocyte-associated immunoglobulin-like receptor 1 Protein, Lair1 Protein, LAIR1 Protein
- 背景
-
Background: Leukocyte associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and are able to spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to "effector" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells, but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells.
Synonym: Leukocyte-associated immunoglobulin-like receptor 1; LAIR-1; mLAIR-1; CD305; Lair1
- 分子量
- 39.6 kDa
-
