LAIR1 Protein (His tag)
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- 抗原 See all LAIR1 蛋白
- LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))
- 蛋白类型
- Recombinant
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宿主
- 猕猴
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资源
- 人细胞
- 标记
- This LAIR1 protein is labelled with His tag.
- 原理
- Recombinant Rhesus Macaque Leukocyte-associated Immunoglobulin-like Receptor 1/LAIR1/CD305 (C-6His)
- 序列
- Gln22-Try165
- 产品特性
- Recombinant Rhesus Macaque Leukocyte-Associated Immunoglobulin-Like Receptor 1 is produced by our Mammalian expression system and the target gene encoding Gln22-Try165 is expressed with a 6His tag at the C-terminus.
- 纯度
- >95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product LAIR1 蛋白
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Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 22-163) protein (His-Avi Tag)
LAIR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 22-163) protein (Fc Tag)LAIR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 22-163) protein (His-Avi Tag,Biotin)LAIR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 22-141) protein (His tag)LAIR1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 22-165) protein (His tag)LAIR1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 22-125), (Extracellular Domain) proteinLAIR1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % by SDS - PAGE SDS
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) protein (mFc Tag)LAIR1 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 1-287) protein (GST tag)LAIR1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 188-287) protein (GST tag)LAIR1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 22-133) protein (His tag)LAIR1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
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- 说明
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25-33 kDa
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))
- 别名
- Leukocyte-associated Immunoglobulin-like Receptor 1/LAIR1/CD305 (LAIR1 产品)
- 别名
- 5133400O11Rik Protein, BB115266 Protein, D7Bwg0421e Protein, Lair-1 Protein, mLair-1 Protein, CD305 Protein, LAIR-1 Protein, leukocyte-associated Ig-like receptor 1 Protein, leukocyte associated immunoglobulin like receptor 1 Protein, leukocyte-associated immunoglobulin-like receptor 1 Protein, Lair1 Protein, LAIR1 Protein
- 背景
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Background: Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) is a single-pass type I membrane protein. LAIR1 expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells, highly in naive T-cells and B-cells. As an inhibitory receptor, LAIR1 plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. LAIR1 plays inhibitory role independently of SH2-containing phosphatases and modulates cytokine production in CD4+ T-cells. It down-regulates IL2 and IFNG production while inducing secretion of transforming growth factor beta, also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. LAIR1 inhibits the differentiation of peripheral blood precursors towards dendritic cells. It also restrains proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells.
Synonym: Leukocyte-Associated Immunoglobulin-Like Receptor 1, LAIR-1, hLAIR1, CD305, LAIR1
- 分子量
- 16.6 kDa
- UniProt
- A0A0U3SBU1
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