LAIR1 Protein (AA 22-163) (His-Avi Tag)
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- 抗原 See all LAIR1 蛋白
- LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 22-163
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This LAIR1 protein is labelled with His-Avi Tag.
- 原理
- Human LAIR1/CD305 Protein
- 序列
- Gln22-His163
- 产品特性
- Recombinant Human LAIR1/CD305 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Gln22-His163.
- 纯度
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- 过滤
- 0.22 μm filtered
- 内毒素水平
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human LAIR1, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-LAIR1 Antibody, hFc Tag with the EC50 of 5.0ng/ml determined by ELISA. The affinity constant of 0.082 nM as determined in SPR assay (Biacore T200). See testing image for detail.
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Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 22-163) protein (Fc Tag)
LAIR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 22-163) protein (His-Avi Tag,Biotin)LAIR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 22-141) protein (His tag)LAIR1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 22-165) protein (His tag)LAIR1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 22-125), (Extracellular Domain) proteinLAIR1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % by SDS - PAGE SDS
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) protein (His tag)LAIR1 宿主: 猕猴 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) protein (mFc Tag)LAIR1 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 1-287) protein (GST tag)LAIR1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 188-287) protein (GST tag)LAIR1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 22-133) protein (His tag)LAIR1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- 缓冲液
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))
- 别名
- LAIR1 (LAIR1 产品)
- 别名
- 5133400O11Rik Protein, BB115266 Protein, D7Bwg0421e Protein, Lair-1 Protein, mLair-1 Protein, CD305 Protein, LAIR-1 Protein, leukocyte-associated Ig-like receptor 1 Protein, leukocyte associated immunoglobulin like receptor 1 Protein, leukocyte-associated immunoglobulin-like receptor 1 Protein, Lair1 Protein, LAIR1 Protein
- 背景
- LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.
- 分子量
- 18.2 kDa. Due to glycosylation, the protein migrates to 30-36 kDa based on Tris-Bis PAGE result.
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