Kallikrein 7 Protein (KLK7) (His tag)
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- 抗原 See all Kallikrein 7 (KLK7) 蛋白
- Kallikrein 7 (KLK7)
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Kallikrein 7 protein is labelled with His tag.
- 原理
- Recombinant Human Kallikrein 7/KLK7 Protein (His Tag)(Active)
- 序列
- Met 1-Arg 253
- 产品特性
- A DNA sequence encoding the human KLK7 (NP_005037.1) extracellular domain (Met 1-Arg 253) was expressed, with a C-terminal polyhistidine tag.
- 纯度
- > 97 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK (Dnp) NH2, R&D Systems, Catalog # ES002. The specific activity is >150 pmoles/min/μg.(Activation description: The proenzyme needs to be activated by Thermolysin for an activated form)
- Top Product
- Discover our top product KLK7 蛋白
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Kallikrein 7 (KLK7) (Active) protein (His tag)
KLK7 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > (71.4+26) % as determined by SDS-PAGE Active
Kallikrein 7 (KLK7) (AA 31-130) protein (GST tag)KLK7 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Kallikrein 7 (KLK7) protein (His tag)KLK7 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Kallikrein 7 (KLK7) (AA 1-253) protein (GST tag)KLK7 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Kallikrein 7 (KLK7) (AA 30-253) protein (His tag)Crystallography grade KLK7 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Kallikrein 7 (KLK7) (AA 26-249) protein (His tag)Crystallography grade KLK7 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- Kallikrein 7 (KLK7)
- 别名
- Kallikrein 7/KLK7 (KLK7 产品)
- 别名
- Prss6 Protein, SCCE Protein, PRSS6 Protein, hK7 Protein, kallikrein related-peptidase 7 (chymotryptic, stratum corneum) Protein, kallikrein-related peptidase 7 Protein, kallikrein related peptidase 7 Protein, Klk7 Protein, KLK7 Protein
- 背景
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Background: Kallikrein-7, also known as kallikrein-related peptidase 7, Stratum corneum chymotryptic enzyme, Serine protease 6, KLK7, and PRSS6, is a secreted protein which belongs to the peptidase S1 family and Kallikrein subfamily. Members of the Kallikrein family are involved in various malignancies such as prostate (PSA, KLK2, KLK15), ovarian (KLK4, KLK5, KLK6, KLK8, KLK10), and breast cancer (KLK10, KLK13, KLK14). Kallikrein-7 / KLK7 appears to be increased in ovarian cancer and higher KLK7 expression in ovarian cancer tissue is associated with poorer prognosis of ovarian cancer patients. Kallikrein-7 / KLK7 is abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Kallikrein-7 / KLK7 is up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at the protein level). It was significantly associated with shorter overall survival (OS) and disease-free survival (DFS). Kallikrein-7 / KLK7 may catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. KLK7 also plays a role in the activation of precursors to inflammatory cytokines.
Synonym: Kallikrein-7; hK7; Serine Protease 6; Stratum Corneum Chymotryptic Enzyme; hSCCE; KLK7; PRSS6; SCCE
- 分子量
- 26.7 kDa
- NCBI登录号
- NP_005037
- 途径
- Complement System
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