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IFNGR1 Protein (His tag)

IFNGR1 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
产品编号 ABIN7320563
发货至: 中国
  • 抗原 See all IFNGR1 蛋白
    IFNGR1 (Interferon gamma Receptor 1 (IFNGR1))
    蛋白类型
    Recombinant
    宿主
    • 13
    • 10
    小鼠
    资源
    • 8
    • 5
    • 5
    • 4
    • 1
    人细胞
    标记
    This IFNGR1 protein is labelled with His tag.
    原理
    Recombinant Mouse IFNGR1 Protein (His Tag)
    序列
    Ala26-Asp253
    产品特性
    Recombinant Mouse Interferon gamma Receptor 1 is produced by our Mammalian expression system and the target gene encoding Ala26-Asp253 is expressed with a 6His tag at the C-terminus.
    纯度
    > 95 % as determined by SDS-PAGE
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product IFNGR1 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    IFNGR1 (Interferon gamma Receptor 1 (IFNGR1))
    别名
    IFNGR1 (IFNGR1 产品)
    别名
    CD119 Protein, IFNGR Protein, IFN-gammaR Protein, Ifgr Protein, Ifngr Protein, Nktar Protein, IFNGR1 Protein, MGC129098 Protein, ifngr1 Protein, MGC194858 Protein, MGC194873 Protein, zgc:194858 Protein, cd119 Protein, ifngr Protein, DKFZp469K1232 Protein, interferon gamma receptor 1 Protein, cytokine receptor family member B17 Protein, IFNGR1 Protein, Ifngr1 Protein, crfb17 Protein, ifngr1 Protein
    背景

    Background: The tetrameric receptor complex for IFNγ consists of two subunits, IFNGR1 (IFNγ Rα) and IFNGR2 (IFNγ Rβ), through which the dimeric IFN-γ exerts its biological functions, including antiviral, antiproliferation and immune-modulatory activity in mammals. Both IFNGR1 and IFNGR2 are single transmembrane proteins belonging to the class II cytokine family. FNGR1, widely expressed in most host cells, is essential for IFNγ binding, receptor trafficking, and signal transduction. IFNGR1 possesses an intracellular Janus tyrosine kinase (JAK) 1 binding site, a signal transducer and activator of transcription 1 (STAT1) binding site. The resulting STAT1 homodimers translocate from the cytoplasm to the nucleus and bind to the interferon-gamma activated sequence (GAS) promoter to induce expression of downstream interferon stimulated genes (ISGs).

    Synonym: CD119, Interferon gamma receptor 1, IFNGR1, IFN-gamma receptor 1, IFN-gamma-R1, CD119 antigen, IFN gamma receptor 1, IFNGR, immune interferon receptor 1, interferon gamma receptor 1, interferon-gamma receptor alpha chain

    分子量
    26.9 kDa
    UniProt
    P15261
    途径
    Interferon-gamma Pathway
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