ICAM2 Protein (His tag,Fc Tag)
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- 抗原 See all ICAM2 蛋白
- ICAM2 (Intercellular Adhesion Molecule 2 (ICAM2))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This ICAM2 protein is labelled with His tag,Fc Tag.
- 原理
- Recombinant Human ICAM-2/CD102 Protein (His & Fc Tag)(Active)
- 序列
- Met 1-Gln 223
- 产品特性
- A DNA sequence encoding the extracellular domain (Met 1-Gln 223) of human ICAM2 (NP_000864.2) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
- 纯度
- > 97 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by the ability of the immobilized protein to support the adhesion of PMA-stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells.When cells are added to ICAM2-coated plates (12.5 μg/mL, 100 μL/well), approximately 50 % - 60 % will adhere specifically.
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Intercellular Adhesion Molecule 2 (ICAM2) protein (Fc Tag)
ICAM2 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Intercellular Adhesion Molecule 2 (ICAM2) (AA 25-223) protein (His tag)ICAM2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Intercellular Adhesion Molecule 2 (ICAM2) (AA 1-275) protein (GST tag)ICAM2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Intercellular Adhesion Molecule 2 (ICAM2) (Active) proteinICAM2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE Active
Intercellular Adhesion Molecule 2 (ICAM2) (Active) protein (Fc Tag)ICAM2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 93 % as determined by SDS-PAGE Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- ICAM2 (Intercellular Adhesion Molecule 2 (ICAM2))
- 别名
- ICAM-2/CD102 (ICAM2 产品)
- 别名
- ICAM2 Protein, CD102 Protein, Icam-2 Protein, Ly-60 Protein, intercellular adhesion molecule 2 Protein, LOC506088 Protein, ICAM2 Protein, LOC616254 Protein, LOC100140873 Protein, Icam2 Protein
- 背景
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Background: Intercellular adhesion molecule 2 (ICAM-2, CD102), belongs to the ICAM family consisting of three members identified as ligands for integrin receptors. It is a type I transmembrane glycoprotein with two Ig-like C2-type domains, and binds to the leukocyte integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). As a second ligand of leukocyte function-associated antigen-1, ICAM-2 functions as a costimulatory molecule for effector cells. ICAM-2 is mainly expressed on vascular endothelial and hematopoietic cells. Interactions of ICAM-2 and the integrin receptors mediate cell adhesion in a wide range of lymphocyte, monocyte, natural killer cell, and granulocytewith other cells, and play important roles in many adhesion-dependent immune and inflammation responses, such as T cell aggregation, NK-cell cytotoxicity and migration, lymphocyte recirculation, etc. Serum levels of ICAM-2 correlated significantly with the inflammatory and course sequences of trichinosis in mice and had a similar relation with blood eosinophilia. So, estimation of ICAM-2 serum levels may prove useful in diagnosis of trichinosis recent infections, and in monitoring the prognosis and response to treatment.
Synonym: Intercellular Adhesion Molecule 2, ICAM-2, CD102, ICAM2
- 分子量
- 50.3 kDa
- NCBI登录号
- NP_000864
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