IGFBP5 Protein (His tag)
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- 抗原 See all IGFBP5 蛋白
- IGFBP5 (Insulin-Like Growth Factor Binding Protein 5 (IGFBP5))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- 人细胞
- 标记
- This IGFBP5 protein is labelled with His tag.
- 原理
- Recombinant Mouse IGFBP-5/IGFBP5 Protein (His Tag)
- 序列
- Leu20-Glu271
- 产品特性
- Recombinant Mouse Insulin-like growth factor-binding protein 5 is produced by our Mammalian expression system and the target gene encoding Leu20-Glu271 is expressed with a 6His tag at the C-terminus.
- 纯度
- > 90 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 21-272) protein (His tag)
IGFBP5 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 21-272) protein (His tag)Crystallography grade IGFBP5 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 20-271) protein (His tag)Crystallography grade IGFBP5 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- IGFBP5 (Insulin-Like Growth Factor Binding Protein 5 (IGFBP5))
- 别名
- IGFBP-5/IGFBP5 (IGFBP5 产品)
- 别名
- IBP5 Protein, AI256729 Protein, AW208790 Protein, IGFBP-5 Protein, IGFBP-5P Protein, IGF-BP5 Protein, igfbp5 Protein, ibp5 Protein, IBP-5 Protein, xIGFBP-5 Protein, IGFBP5 Protein, igfbp5b Protein, zgc:165472 Protein, insulin like growth factor binding protein 5 Protein, insulin-like growth factor binding protein 5 Protein, insulin like growth factor binding protein 5 L homeolog Protein, insulin-like growth factor binding protein 5b Protein, insulin-like growth factor-binding protein 5 Protein, insulin-like growth factor binding protein 5a Protein, IGFBP5 Protein, Igfbp5 Protein, igfbp5.L Protein, igfbp5b Protein, igfbp5 Protein, LOC100194500 Protein, igfbp5a Protein
- 背景
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Background: Mouse Insulin-like growth factor-binding protein 5(IGFBP-5) belongs to the superfamily of insulin-like growth factor (IGF) binding proteins. It contains 1 IGFBP N-terminal domain and 1 thyroglobulin type-1 domain. Mouse IGFBP-5 shows 97 % aa sequence identity with those of human and rat IGFBP-5. It is expressed mostly in kidney, uterus and gastrocnemius muscle. It also expressed by fibroblasts, myoblasts and osteoblasts, making it the predominant IGFBP found in bone extracts. IGFBP-5 has a strong affinity for hydroxyapatite, allowing it to bind to bone cells. When bound to extracelluar matrix, IGFBP-5 is protected from proteolysis and potentiates IGF activity, but when it is soluble, IGFBP-5 is cleaved to a biologically inactive 21 kDa fragment. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Synonym: BP-5, IGFBP-5, IGF-binding protein 5, Insulin-like growth factor-binding protein 5,
- 分子量
- 29.3 kDa
- UniProt
- Q07079
- 途径
- WNT signaling, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Growth Factor Binding
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