ICOSLG Protein (His tag,Fc Tag)
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- 抗原 See all ICOSLG 蛋白
- ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This ICOSLG protein is labelled with His tag,Fc Tag.
- 原理
- Recombinant Mouse ICOS Ligand/ICOSL Protein (His & Fc Tag)(Active)
- 序列
- Met 1-Lys 279
- 产品特性
- A DNA sequence encoding the mouse B7-H2 (NP_056605.1) extracellular domain (Met 1-Lys 279) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
- 纯度
- > 95 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA. Immobilized human ICOS at 1 μg/ml (100 μl/well) can bind biotinylated mouse B7-H2 Fc chimera with a linear range of 0.125-1.0 μg/ml.
- Top Product
- Discover our top product ICOSLG 蛋白
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Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-258) protein (His-Avi Tag)
ICOSLG 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-258) protein (Fc Tag)ICOSLG 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) protein (His-Avi Tag,Biotin)ICOSLG 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 47-279) protein (His tag)ICOSLG 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-256) protein (His tag)ICOSLG 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 18-135) protein (His-DYKDDDDK-Strep II Tag)ICOSLG 宿主: 人 宿主: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 18-256) protein (His-DYKDDDDK-Strep II Tag)ICOSLG 宿主: 人 宿主: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) protein (mFc-His Tag)ICOSLG 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. FACS
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 20-302) protein (GST tag)ICOSLG 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (Active) protein (His tag)ICOSLG 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))
- 别名
- ICOS Ligand/ICOSL (ICOSLG 产品)
- 别名
- ICOSLG Protein, AU044799 Protein, B7-H2 Protein, B7RP-1 Protein, B7h Protein, BG071784 Protein, GI50 Protein, GL50 Protein, GL50-B Protein, ICOS-L Protein, Icoslg Protein, LICOS Protein, Ly115l Protein, mKIAA0653 Protein, B7H2 Protein, B7RP1 Protein, CD275 Protein, ICOSL Protein, Icosl Protein, RGD1562791 Protein, inducible T-cell costimulator ligand Protein, icos ligand Protein, inducible T-cell co-stimulator ligand Protein, ICOSLG Protein, Icosl Protein, Icoslg Protein
- 背景
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Background: Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.Immune CheckpointImmune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: FCM Antibodies Immune Checkpoint Detection: WB AntibodiesImmune Checkpoint Targets Co-stimulatory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: Icosl, AU044799, B7-H2, B7RP-1, B7h, BG071784, GI50, GL50, GL50-B, ICOS-L, KIAA0653, LICOS, Ly115l, Mkiaa0653
- 分子量
- 54.3 kDa
- NCBI登录号
- NP_056605
- 途径
- Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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