GM2A Protein (His tag)
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- 抗原 See all GM2A 蛋白
- GM2A (GM2 Ganglioside Activator (GM2A))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This GM2A protein is labelled with His tag.
- 原理
- Recombinant Human GM2A Protein (Baculovirus, His Tag)
- 序列
- Met 1-Ile 193
- 产品特性
- A DNA sequence encoding the human GM2A (AAA35907.1) (Met 1-Ile 193) was fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 96 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product GM2A 蛋白
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GM2 Ganglioside Activator (GM2A) (AA 26-193) protein (His tag)
GM2A 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
GM2 Ganglioside Activator (GM2A) (AA 1-193) protein (GST tag)GM2A 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
GM2 Ganglioside Activator (GM2A) (AA 94-193) protein (GST tag)GM2A 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- GM2A (GM2 Ganglioside Activator (GM2A))
- 别名
- GM2A (GM2A 产品)
- 别名
- GM2A Protein, fb96e04 Protein, fb96e10 Protein, wu:fb96e04 Protein, wu:fb96e10 Protein, zgc:110188 Protein, MGC84154 Protein, GM2-AP Protein, SAP-3 Protein, AA408702 Protein, AW215435 Protein, GM2 ganglioside activator Protein, GM2 ganglioside activator L homeolog Protein, GM2 ganglioside activator protein Protein, Gm2a Protein, GM2A Protein, gm2a Protein, gm2a.L Protein
- 背景
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Background: GM2A (GM2 ganglioside activator), is a lipid transfer protein which belongs to the ML domain family. GM2A can accommodate several single chain phospholipids and fatty acids. It also exhibits some calcium-independent phospholipase activity. GM2A binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. GM2A acts as a substrate specific co-factor for the lysosomal enzyme β-hexosaminidase A. β-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Defects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB), also known as Tay-Sachs disease AB variant.
Synonym: Ganglioside GM2 activator;Cerebroside sulfate activator protein;GM2-AP;Sphingolipid activator protein 3;SAP-3
- 分子量
- 19.8 kDa
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