FZD1 Protein (His tag)
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- 抗原 See all FZD1 (Fzd1) 蛋白
- FZD1 (Fzd1) (Frizzled Family Receptor 1 (Fzd1))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This FZD1 protein is labelled with His tag.
- 原理
- Recombinant Mouse Frizzled 1/FZD1 Protein (His Tag)
- 序列
- Met 1-His 248
- 产品特性
- A DNA sequence encoding the mouse FZD1 (NP_067432.2) extracellular domain (Met 1-His 248) was expressed with a polyhistidine tag at the C-terminus.
- 纯度
- > 97 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product Fzd1 蛋白
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Frizzled Family Receptor 1 (Fzd1) protein (Fc Tag)
Fzd1 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- FZD1 (Fzd1) (Frizzled Family Receptor 1 (Fzd1))
- 别名
- Frizzled 1/FZD1 (Fzd1 产品)
- 别名
- CG17697 Protein, CG3646 Protein, DFZ1 Protein, DFz Protein, DFz1 Protein, Dfz1 Protein, Dm Fz1 Protein, Dmel\\CG17697 Protein, FZ Protein, Frz Protein, Fz Protein, Fz1 Protein, frz Protein, fz1 Protein, fz[[1]] Protein, Fz-1 Protein, cFz-1 Protein, Xfrizzled-1 Protein, frizzled1 Protein, frz-1 Protein, frz1 Protein, fzd1-A Protein, AW227548 Protein, FZ-1 Protein, frizzled Protein, frizzled class receptor 1 Protein, frizzled class receptor 1 L homeolog Protein, fz Protein, FZD1 Protein, Fzd1 Protein, fzd1.L Protein
- 背景
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Background: Frizzled-1, also known as FZD1, belongs to the G-protein coupled receptor Fz/Smo family. FZD1 contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. FZD1 is expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney. Frizzled is a family of G protein-coupled receptor proteins that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol. Frizzled proteins and the genes encoding them have been identified in an array of animals, from sponges to humans. Frizzled proteins play key roles in governing cell polarity, embryonic development, formation of neural synapses, cell proliferation, and many other processes in developing and adult organisms. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.
Synonym: Frizzled-1; Fz-1; mFz1; Fzd1; Frizzled homolog 1
- 分子量
- 21 kDa
- NCBI登录号
- NP_067432
- 途径
- WNT signaling, Asymmetric Protein Localization
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