FOLR1 Protein (Fc Tag)
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- 抗原 See all FOLR1 蛋白
- FOLR1 (Folate Receptor 1 (Adult) (FOLR1))
- 蛋白类型
- Recombinant
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宿主
- 大鼠
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资源
- HEK-293 Cells
- 标记
- This FOLR1 protein is labelled with Fc Tag.
- 原理
- Recombinant Rat FOLR1 Protein (Fc Tag)
- 序列
- Met1-Met231
- 产品特性
- A DNA sequence encoding the rat Folr1 (NP_598211.1) (Met1-Met231) was expressed with the Fc region of human IgG1 at the C-terminus.
- 纯度
- > 85 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg protein as determined by the LAL method.
- Top Product
- Discover our top product FOLR1 蛋白
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Folate Receptor 1 (Adult) (FOLR1) (AA 25-233) protein (His-Avi Tag)
FOLR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Folate Receptor 1 (Adult) (FOLR1) (AA 25-233) protein (Fc Tag)FOLR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Folate Receptor 1 (Adult) (FOLR1) (AA 25-233) protein (His tag)FOLR1 宿主: 猕猴, Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Folate Receptor 1 (Adult) (FOLR1) protein (His-Avi Tag,Biotin)FOLR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Folate Receptor 1 (Adult) (FOLR1) (AA 25-232) protein (His tag)FOLR1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Folate Receptor 1 (Adult) (FOLR1) (AA 25-233) (Active) protein (His tag)FOLR1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Folate Receptor 1 (Adult) (FOLR1) (AA 25-233) (Active) protein (His tag)FOLR1 宿主: 猕猴, Cynomolgus 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Folate Receptor 1 (Adult) (FOLR1) (AA 25-233) (Active) protein (Fc Tag,AVI tag,Biotin)FOLR1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Folate Receptor 1 (Adult) (FOLR1) (AA 25-233) (Active) protein (His tag,AVI tag,Biotin)FOLR1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Folate Receptor 1 (Adult) (FOLR1) (AA 25-233) protein (Strep Tag)FOLR1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- FOLR1 (Folate Receptor 1 (Adult) (FOLR1))
- 别名
- FOLR1 (FOLR1 产品)
- 别名
- FBP Protein, FOLR Protein, fbp Protein, folr Protein, folr1 Protein, FBP1 Protein, Folbp-1 Protein, Folbp1 Protein, Fbp1 Protein, FOLR1 Protein, Folr1 Protein, folate receptor 1 Protein, folate receptor 1 (adult) Protein, folate receptor 1 (adult) L homeolog Protein, zgc:165502 Protein, Folate receptor alpha Protein, folate receptor alpha Protein, FOLR1 Protein, folr1 Protein, folr1.L Protein, zgc:165502 Protein, Folr1 Protein, LOC100066084 Protein, LOC100725439 Protein
- 背景
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Background: The protein encoded by FOLR1 gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. Folate receptor α (FRα) is the most important subunit of Folate receptor and the alpha isoform has been shown to be selectively overexpressed in cancer types like breast and ovarian cancer compared to normal breast and ovarian epithelial cells. It was determined that Folate receptor α exhibits a limited expression on the apical surfaces of the epithelial cells of normal lung, breast, thyroid, parathyroid, and kidney tissues. For their uptake of folate, normal cells rely almost exclusively on the reduced folate carrier, whereas many carcinomas and myeloid leukemia cells overexpress a high-affinity FR on their surfaces, perhaps reflecting their increased need for folate to support rapid cell divisionImmune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: FOLR1
- 分子量
- 50.9 kDa
- NCBI登录号
- NP_598211
- 途径
- Dicarboxylic Acid Transport
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