FGFR4 Protein (His tag)
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- 抗原 See all FGFR4 蛋白
- FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))
- 蛋白类型
- Recombinant
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宿主
- 大鼠
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资源
- HEK-293 Cells
- 标记
- This FGFR4 protein is labelled with His tag.
- 原理
- Recombinant Rat FGFR4/CD334 Protein (His Tag)
- 序列
- Met1-Asp367
- 产品特性
- A DNA sequence encoding the rat FGFR4 (Q498D6) (Met1-Asp367) was expressed, fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 95 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method
- Top Product
- Discover our top product FGFR4 蛋白
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Fibroblast Growth Factor Receptor 4 (FGFR4) (AA 22-369) protein (Fc Tag)
FGFR4 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Fibroblast Growth Factor Receptor 4 (FGFR4) (AA 22-369) protein (His-Avi Tag)FGFR4 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Fibroblast Growth Factor Receptor 4 (FGFR4) (AA 22-369) protein (His tag)FGFR4 宿主: 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Fibroblast Growth Factor Receptor 4 (FGFR4) protein (His-Avi Tag,Biotin)FGFR4 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Fibroblast Growth Factor Receptor 4 (FGFR4) (AA 460-802) (Active) protein (GST tag)FGFR4 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Fibroblast Growth Factor Receptor 4 (FGFR4) (Asn535Lys-Mutant) (Active) protein (GST tag)FGFR4 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Fibroblast Growth Factor Receptor 4 (FGFR4) (Val550Glu-Mutant) (Active) protein (GST tag)FGFR4 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Fibroblast Growth Factor Receptor 4 (FGFR4) (Val550Leu-Mutant) (Active) protein (GST tag)FGFR4 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Fibroblast Growth Factor Receptor 4 (FGFR4) (AA 391-802) (Active) protein (His-GST)FGFR4 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
Fibroblast Growth Factor Receptor 4 (FGFR4) (AA 1-802) protein (GST tag)FGFR4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))
- 别名
- FGFR4/CD334 (FGFR4 产品)
- 别名
- FGFR4 Protein, XFGFR-4 Protein, XFGFR-4a Protein, cd334 Protein, fgfr-4 Protein, jtk2 Protein, tkf Protein, xfgfr4 Protein, CD334 Protein, JTK2 Protein, TKF Protein, Fgfr-4 Protein, etID309818.21 Protein, wu:fc13h10 Protein, zgc:111935 Protein, fgfr-4c Protein, fgfr4 Protein, fibroblast growth factor receptor 4 Protein, fibroblast growth factor receptor 4 S homeolog Protein, FGFR4 Protein, fgfr4 Protein, Fgfr4 Protein, fgfr4.S Protein
- 背景
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Background: Fibroblast growth factor receptor 4 (FGFR4) also known as CD334 antigen or tyrosine kinase related to fibroblast growth factor receptor, is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR4/CD334 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR4/CD334 preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. FGFR4/CD334 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4/CD334. Mutations in FGFR4/CD334 lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: FGFR-4
- 分子量
- 40.3 kDa
- UniProt
- Q498D6
- 途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
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