FGFR4 Protein (AA 22-369) (Fc Tag)
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- 抗原 See all FGFR4 蛋白
- FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))
- 蛋白类型
- Recombinant
- 产品特性
- AA 22-369
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This FGFR4 protein is labelled with Fc Tag.
- 原理
- Human FGFR4 Protein
- 序列
- Leu22-Asp369
- 产品特性
- Recombinant Human FGFR4 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Leu22-Asp369.
- 纯度
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- 过滤
- 0.22 μm filtered
- 内毒素水平
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- The affinity constant of 13.05 nM as determined in SPR assay (Biacore T200). See testing image for detail.
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Fibroblast Growth Factor Receptor 4 (FGFR4) (AA 22-369) protein (His-Avi Tag)
FGFR4 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Fibroblast Growth Factor Receptor 4 (FGFR4) (AA 22-369) protein (His tag)FGFR4 宿主: 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Fibroblast Growth Factor Receptor 4 (FGFR4) protein (His-Avi Tag,Biotin)FGFR4 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Fibroblast Growth Factor Receptor 4 (FGFR4) (AA 460-802) (Active) protein (GST tag)FGFR4 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Fibroblast Growth Factor Receptor 4 (FGFR4) (Asn535Lys-Mutant) (Active) protein (GST tag)FGFR4 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Fibroblast Growth Factor Receptor 4 (FGFR4) (Val550Glu-Mutant) (Active) protein (GST tag)FGFR4 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Fibroblast Growth Factor Receptor 4 (FGFR4) (Val550Leu-Mutant) (Active) protein (GST tag)FGFR4 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Fibroblast Growth Factor Receptor 4 (FGFR4) (AA 391-802) (Active) protein (His-GST)FGFR4 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
Fibroblast Growth Factor Receptor 4 (FGFR4) (AA 1-802) protein (GST tag)FGFR4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Fibroblast Growth Factor Receptor 4 (FGFR4) (AA 31-145) protein (GST tag)FGFR4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- 缓冲液
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))
- 别名
- FGFR4 (FGFR4 产品)
- 别名
- FGFR4 Protein, XFGFR-4 Protein, XFGFR-4a Protein, cd334 Protein, fgfr-4 Protein, jtk2 Protein, tkf Protein, xfgfr4 Protein, CD334 Protein, JTK2 Protein, TKF Protein, Fgfr-4 Protein, etID309818.21 Protein, wu:fc13h10 Protein, zgc:111935 Protein, fgfr-4c Protein, fgfr4 Protein, fibroblast growth factor receptor 4 Protein, fibroblast growth factor receptor 4 S homeolog Protein, FGFR4 Protein, fgfr4 Protein, Fgfr4 Protein, fgfr4.S Protein
- 背景
- Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19.
- 分子量
- 65.3 kDa. Due to glycosylation, the protein migrates to 80-95 kDa based on Tris-Bis PAGE result.
- UniProt
- P22455
- 途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
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