FGFR3 Protein (His tag)
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- 抗原 See all FGFR3 蛋白
- FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This FGFR3 protein is labelled with His tag.
- 原理
- Recombinant Mouse FGFR3 Protein (His Tag)(Active)
- 序列
- Met 1-Tyr 367
- 产品特性
- A DNA sequence encoding the extracellular domain (Met 1-Tyr 367) of mouse FGFR3 (NP_032036.2) was expressed, fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 98 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to inhibit FGF acidic dependent proliferation of Balb/c3T3 mouse embryonic fibroblasts.The ED50 for this effect is typically 0.3-4 μg/mL.
- Top Product
- Discover our top product FGFR3 蛋白
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Fibroblast Growth Factor Receptor 3 (FGFR3) (Lys650Glu-Mutant) (Active) protein (GST tag)
FGFR3 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 436-806) (Active) protein (GST tag)FGFR3 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Fibroblast Growth Factor Receptor 3 (FGFR3) (Lys650Met-Mutant) (Active) protein (GST tag)FGFR3 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 23-320) protein (His tag)FGFR3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 1-372) protein (His-Fc tag)FGFR3 宿主: 人 宿主: HEK-293T Cells Recombinant SDS, Func
Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 27-126) protein (GST tag)FGFR3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Fibroblast Growth Factor Receptor 3 (FGFR3) (Active) protein (His tag,Fc Tag)FGFR3 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 92 % as determined by SDS-PAGE Active
Fibroblast Growth Factor Receptor 3 (FGFR3) protein (Fc Tag)FGFR3 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 23-375) protein (His tag)Crystallography grade FGFR3 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 397-806) protein (His tag)Crystallography grade FGFR3 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))
- 别名
- FGFR3 (FGFR3 产品)
- 别名
- FGFR3 Protein, LOC100034114 Protein, ACH Protein, CD333 Protein, CEK2 Protein, HSFGFR3EX Protein, JTK4 Protein, FR3 Protein, Fgfr-3 Protein, Flg-2 Protein, HBGFR Protein, Mfr3 Protein, sam3 Protein, fc27h01 Protein, wu:fc27h01 Protein, fibroblast growth factor receptor 3 Protein, fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) S homeolog Protein, FGFR3 Protein, fgfr3.S Protein, Fgfr3 Protein, fgfr3 Protein
- 背景
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Background: FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. Mutations in FGFR genes are the cause of several human developmental disorders characterized by skeletal abnormalities such as achondroplasia, and upregulation of FGFR expression may lead to cell transformation and cancer. FGFR3, a full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR3 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR3 binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. CD333 is the receptor for acidic and basic fibroblast growth factors.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: CD333;Fgfr-3;Flg-2;FR3;HBGFR;Mfr3;sam3
- 分子量
- 37 kDa
- NCBI登录号
- NP_032036
- 途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Growth Factor Binding
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