EPH Receptor B6 Protein (EPHB6) (Fc Tag)
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- 抗原 See all EPH Receptor B6 (EPHB6) 蛋白
- EPH Receptor B6 (EPHB6)
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This EPH Receptor B6 protein is labelled with Fc Tag.
- 原理
- Recombinant Human EphB6 Protein (Fc Tag)(Active)
- 序列
- Met 1-Ser 579
- 产品特性
- The extracellular domain (Met 1-Ser 579) of human EphB6 (NP_004436.1) precursor was fused with the Fc region of human IgG1 at the C-terminus.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- 1. Measured by its binding ability in a functional ELISA.2. Immobilized recombinant human EphrinB1 at 10 μg/ml (100 μl/well) can bind human EphB6 with a linear range of 0.16-4 μg/ml.3. Immobilized recombinant human EphrinB2 at 10 μg/ml (100 μl/well) can bind human EphB6 with a linear range of 1.28-32 ng/ml.
- Top Product
- Discover our top product EPHB6 蛋白
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EPH Receptor B6 (EPHB6) (AA 23-122) protein (GST tag)
EPHB6 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
EPH Receptor B6 (EPHB6) (AA 616-1021) protein (His tag)Crystallography grade EPHB6 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS
EPH Receptor B6 (EPHB6) (AA 613-1014) protein (His tag)Crystallography grade EPHB6 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS
EPH Receptor B6 (EPHB6) (AA 32-594) protein (His tag)Crystallography grade EPHB6 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS
EPH Receptor B6 (EPHB6) (AA 33-591) protein (His tag)Crystallography grade EPHB6 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS
EPH Receptor B6 (EPHB6) (AA 32-1021) protein (rho-1D4 tag)Crystallography grade EPHB6 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS
EPH Receptor B6 (EPHB6) (AA 33-1014) protein (rho-1D4 tag)Crystallography grade EPHB6 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS
EPH Receptor B6 (EPHB6) protein (DYKDDDDK-His Tag)EPHB6 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- EPH Receptor B6 (EPHB6)
- 别名
- EphB6 (EPHB6 产品)
- 别名
- CEK9 Protein, EPHB5 Protein, Cekl Protein, Mep Protein, HEP Protein, EPH receptor B6 Protein, Eph receptor B6 Protein, EPHB6 Protein, Ephb6 Protein
- 背景
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Background: Ephrins are divided into the ephrin-A (EFNA) class and the ephrin-B (EFNB) class based on their structures and sequence relationships. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB6 is an unusual Eph receptor, lacking catalytic capacity due to alterations in its kinase domain. Interestingly, increased metastatic activity is associated with reduced EphB6 receptor expression in several tumor types, including breast cancer. This emphasizes the potential of EphB6 to act as a suppressor of cancer aggressiveness. EphB6 suppress cancer invasiveness through c-Cbl-dependent signaling, morphologic changes, and cell attachment and indicate that EphB6 may represent a useful prognostic marker and a promising target for therapeutic approaches. EphB6 can both positively and negatively regulate cell adhesion and migration, and suggest that tyrosine phosphorylation of the receptor by an Src family kinase acts as the molecular switch for the functional transition. In addition, Ephrin-B2 may be a physiological ligand for the EphB6 receptor.
Synonym: HEP
- 分子量
- 86.5 kDa
- NCBI登录号
- NP_004436
- 途径
- RTK signaling, Hormone Transport
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