EPH Receptor A2 Protein (EPHA2) (Fc Tag)
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- 抗原 See all EPH Receptor A2 (EPHA2) 蛋白
- EPH Receptor A2 (EPHA2)
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- 人细胞
- 标记
- This EPH Receptor A2 protein is labelled with Fc Tag.
- 原理
- Recombinant Human EphA2 Protein (Fc Tag)(Active)
- 序列
- Ala24-Asn534
- 产品特性
- Recombinant Human Ephrin A Receptor 2 is produced by our Mammalian expression system and the target gene encoding Ala24-Asn534 is expressed with a Fc tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Immobilized Human Ephrin-A1-His(Cat: PKSH032388) at 1.5μg/ml(100 μl/well) can bind Human EphA2-Fc. The ED50 of Human EphA2-Fc is 12.43 ug/ml.
- Top Product
- Discover our top product EPHA2 蛋白
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EPH Receptor A2 (EPHA2) (AA 24-537) protein (His tag)
EPHA2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
EPH Receptor A2 (EPHA2) (AA 26-538) protein (His tag)EPHA2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
EPH Receptor A2 (EPHA2) (AA 24-534) protein (His-Avi Tag)EPHA2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
EPH Receptor A2 (EPHA2) (AA 24-534) protein (Fc Tag)EPHA2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
EPH Receptor A2 (EPHA2) (AA 204-326) protein (GST tag)EPHA2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
EPH Receptor A2 (EPHA2) (AA 1-976) protein (GST tag)EPHA2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
EPH Receptor A2 (EPHA2) (AA 585-976) (Active) protein (GST tag,His tag)EPHA2 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
EPH Receptor A2 (EPHA2) (Active) protein (His tag)EPHA2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- EPH Receptor A2 (EPHA2)
- 别名
- EphA2 (EPHA2 产品)
- 别名
- ARCC2 Protein, CTPA Protein, CTPP1 Protein, CTRCT6 Protein, ECK Protein, epha2 Protein, MGC89505 Protein, AW545284 Protein, Eck Protein, Myk2 Protein, Sek-2 Protein, Sek2 Protein, id:ibd5152 Protein, rtk6 Protein, G42 Protein, XE10 Protein, epha2-A Protein, EPH receptor A2 Protein, Eph receptor A2 Protein, epoxide hydrolase Protein, eph receptor A2 a Protein, EPH receptor A2 L homeolog Protein, EPHA2 Protein, Epha2 Protein, epha2 Protein, ephA2 Protein, epha2a Protein, epha2.L Protein
- 背景
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Background: Ephrin type-A receptor 2/EphA2 is a member of the Eph receptor tyrosine kinase family which binds Ephrins A1, 2, 3, 4, and 5. A and B class Eph proteins have a common structural organization. Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. EphA2 becomes autophosphorylated following ligand binding and then interacts with SH2 domain-containing PI3-kinase to activate MAPK pathways. Reverse signaling is also propagated through the Ephrin ligand. Transcription of EphA2 is dependent on the expression of E-Cadherin, and can be induced by p53 family transcription factors. EphA2 is upregulated in breast, prostate, and colon cancer vascular endothelium. Its ligand, EphrinA1, is expressed by the local tumor cells. In some cases, EphA2 and EphrinA1 are expressed on the same blood vessels. EphA2 signaling cooperates with VEGF receptor signaling in promoting endothelial cell migration.
Synonym: Ephrin type-A receptor 2, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, EPHA2,ARCC2,CTPA,CTPP1,CTRCT6,ECK
- 分子量
- 83.0 kDa
- UniProt
- P29317
- 途径
- RTK signaling
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