EPH Receptor A2 Protein (EPHA2) (AA 585-976) (GST tag,His tag)
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- 抗原 See all EPH Receptor A2 (EPHA2) 蛋白
- EPH Receptor A2 (EPHA2)
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 585-976
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This EPH Receptor A2 protein is labelled with GST tag,His tag.
- 原理
- Recombinant Human EphA2 Protein (aa 585-976, His & GST Tag)(Active)
- 序列
- Leu 585-Ile 976
- 产品特性
- A DNA sequence encoding the human EPHA2 (P29317) (Leu585-Ile976) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- The specific activity was determined to be 50 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.
- Top Product
- Discover our top product EPHA2 蛋白
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EPH Receptor A2 (EPHA2) (AA 24-537) protein (His tag)
EPHA2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
EPH Receptor A2 (EPHA2) (AA 26-538) protein (His tag)EPHA2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
EPH Receptor A2 (EPHA2) (AA 24-534) protein (His-Avi Tag)EPHA2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
EPH Receptor A2 (EPHA2) (AA 24-534) protein (Fc Tag)EPHA2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
EPH Receptor A2 (EPHA2) (AA 585-976) (Active) protein (His-GST)EPHA2 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
EPH Receptor A2 (EPHA2) (AA 204-326) protein (GST tag)EPHA2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
EPH Receptor A2 (EPHA2) (AA 1-976) protein (GST tag)EPHA2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
EPH Receptor A2 (EPHA2) (Active) protein (His tag)EPHA2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE Active
EPH Receptor A2 (EPHA2) (AA 559-976) protein (His tag)Crystallography grade EPHA2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
EPH Receptor A2 (EPHA2) (AA 560-977) protein (His tag)Crystallography grade EPHA2 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 20 mM Tris, 500 mM NaCl, 3 mM DTT, pH 8.5, 10 % glycerol
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- EPH Receptor A2 (EPHA2)
- 别名
- EphA2 (EPHA2 产品)
- 别名
- ARCC2 Protein, CTPA Protein, CTPP1 Protein, CTRCT6 Protein, ECK Protein, epha2 Protein, MGC89505 Protein, AW545284 Protein, Eck Protein, Myk2 Protein, Sek-2 Protein, Sek2 Protein, id:ibd5152 Protein, rtk6 Protein, G42 Protein, XE10 Protein, epha2-A Protein, EPH receptor A2 Protein, Eph receptor A2 Protein, epoxide hydrolase Protein, eph receptor A2 a Protein, EPH receptor A2 L homeolog Protein, EPHA2 Protein, Epha2 Protein, epha2 Protein, ephA2 Protein, epha2a Protein, epha2.L Protein
- 背景
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Background: Eph receptor A2 (Ephrin type-A receptor 2 or EphA2) is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptors' corresponding family of ligands are the ephrins anchored to cell surfaces. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps. They have also been found implicated in embryonic patterning, neuronal targeting, vascular development and adult neovascularization. The large family of ligands and receptors may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system. Furthermore, elevated expression of Eph receptors and ephrin ligands is associated with tumors and associated tumor vasculature, suggesting the Eph receptors and ephrin ligands also play critical roles in tumor angiogenesis and tumor growth. Unlike most Eph kinases, which are primarily expressed during development, EphA2 is primarily found in adult human epithelial cells. The cellular functions of EphA2 may be regulating cell growth, survival, migration, and angiogenesis.Unlike other receptor tyrosine kinases, ligand binding is not necessary for EphA2. Rather, the ligand appears to regulate EphA2 subcellular localization and its interactions with downstream adapter and signaling proteins. Eph receptor A2(EphA2) has been demonstrated to critically regulate tumor cell growth, migration and invasiveness. Eph receptor A2(EphA2) is frequently overexpressed and functionally altered in aggressive tumor cells, and that these changes promote metastatic character.
Synonym: Ephrin type-A receptor 2, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, EPHA2,ARCC2,CTPA,CTPP1,CTRCT6,ECK
- 分子量
- 72.1 kDa
- UniProt
- P29317
- 途径
- RTK signaling
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