DNMT1 Protein (His tag)
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- 抗原 See all DNMT1 蛋白
- DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))
- 蛋白类型
- Recombinant
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宿主
- 大鼠
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资源
- 大肠杆菌（E. Coli）
- 标记
- This DNMT1 protein is labelled with His tag.
- 原理
- Recombinant Rat DNMT1 Protein (His Tag)
- 序列
- Phe950-Pro1142
- 产品特性
- A DNA sequence encoding the Rat DNMT1 (Q9Z330-1) (Phe950-Pro1142) was expressed with a polyhistidine tag at the N-terminus.
- 纯度
- >80 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product DNMT1 蛋白
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DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (Active) protein
DNMT1 宿主: 小鼠 宿主: Insect Cells Recombinant > 95 % protein determined by SDS-PAGE (CBB staining) Active
DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) protein (His tag)DNMT1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >80 % as determined by reducing SDS-PAGE.
DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1-110) protein (GST tag)DNMT1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1-1616) protein (Strep Tag)Crystallography grade DNMT1 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1-1620) protein (Strep Tag)Crystallography grade DNMT1 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (Transcript Variant 1) (Active) protein (Myc-DYKDDDDK Tag)DNMT1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining STD, AbP, Func, PI Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))
- 别名
- DNMT1 (DNMT1 产品)
- 别名
- cb1075 Protein, cb983 Protein, dmnt1 Protein, fb05h01 Protein, mta Protein, wu:fb05h01 Protein, ADCADN Protein, AIM Protein, CXXC9 Protein, DNMT Protein, HSN1E Protein, MCMT Protein, DDM2 Protein, DECREASED DNA METHYLATION 2 Protein, DMT01 Protein, DMT1 Protein, DNA METHYLTRANSFERASE Protein, DNA METHYLTRANSFERASE 01 Protein, DNA METHYLTRANSFERASE 1 Protein, MET2 Protein, METHYLTRANSFERASE 2 Protein, METHYLTRANSFERASE I Protein, METI Protein, methyltransferase 1 Protein, Cxxc9 Protein, Dnmt Protein, Dnmt1o Protein, MTase Protein, Met-1 Protein, Met1 Protein, MommeD2 Protein, m.MmuI Protein, DNA methyltransferase 1 Protein, DNA (cytosine-5-)-methyltransferase 1 Protein, methyltransferase 1 Protein, DNA methyltransferase (cytosine-5) 1 Protein, DNMT1 Protein, dnmt1 Protein, Dnmt1 Protein, MET1 Protein
- 背景
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Background: Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. Promotes tumor growth.
Synonym: DNA (cytosine-5)-methyltransferase 1,Dnmt1,Met-1,DNA methyltransferase MmuI,DNA MTase MmuI,M.MmuI,MCMT,Dnmt, Met1, Uim
- 分子量
- 22.01 kDa
- 途径
- SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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