DKK2 Protein (His tag,Fc Tag)
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- 抗原 See all DKK2 蛋白
- DKK2 (Dickkopf 2 Homolog (DKK2))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 人细胞
- 标记
- This DKK2 protein is labelled with His tag,Fc Tag.
- 原理
- Recombinant Human DKK2 Protein (His&Fc Tag)
- 序列
- Asp251-Ile526
- 产品特性
- Recombinant Human Dickkopf-related protein 2 is produced by our Mammalian expression system and the target gene encoding Asp251-Ile526 is expressed with a Fc tag at the N-terminus, 6His tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product DKK2 蛋白
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Dickkopf 2 Homolog (DKK2) (AA 34-100) protein (His-IF2DI Tag)
DKK2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Dickkopf 2 Homolog (DKK2) (AA 34-259) protein (His tag)DKK2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant SDS
Dickkopf 2 Homolog (DKK2) (AA 34-259) protein (His tag)Crystallography grade DKK2 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Dickkopf 2 Homolog (DKK2) (AA 34-259) protein (His tag)Crystallography grade DKK2 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Dickkopf 2 Homolog (DKK2) (AA 34-259) protein (His-SUMO Tag)DKK2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.2.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- DKK2 (Dickkopf 2 Homolog (DKK2))
- 别名
- DKK2 (DKK2 产品)
- 别名
- DKK-2 Protein, Dkk4 Protein, zgc:171574 Protein, dickkopf WNT signaling pathway inhibitor 2 Protein, DKK2 Protein, Dkk2 Protein, dkk2 Protein
- 背景
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Background: Dickkopf-related protein 2 (DKK2), is a member of the dickkopf family. DKK2 is secreted protein which contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Synonym: Dickkopf-related protein 2, Dickkopf-2, Dkk-2, hDkk-2
- 分子量
- 58.9 kDa
- UniProt
- Q9UBU2
- 途径
- WNT signaling
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