CSF1R Protein (Fc Tag)
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- 抗原 See all CSF1R 蛋白
- CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 大鼠
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资源
- HEK-293 Cells
- 标记
- This CSF1R protein is labelled with Fc Tag.
- 原理
- Recombinant Rat CSF1R/CD115 Protein (Fc Tag)(Active)
- 序列
- Met1-Glu510
- 产品特性
- A DNA sequence encoding the rat CSF1R (D4ACA7) (Met1-Glu510) was expressed with the Fc region of human IgG1 at the C-terminus.
- 纯度
- > 95 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method
- Biological Activity Comment
- 1. Immobilized rat CSF1R-Fc at 10 μg/ml (100 μl/well) can bind biotinylated human CSF1-His, The EC50 of biotinylated human CSF1-His is 1.7-3.9 ng/ml.2. Measured by its ability to inhibit mouse CSF induced proliferation of M-NFS-60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is typically 0.015-0.06 μg/mL in the presence of 2.5 ng/ml Recombinant Mouse M-CSF.
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- Discover our top product CSF1R 蛋白
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Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-512) protein (Fc Tag)
CSF1R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 99-596) protein (His tag)CSF1R 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Colony Stimulating Factor 1 Receptor (CSF1R) protein (His-Avi Tag,Biotin)CSF1R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-512) protein (His-Avi Tag)CSF1R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-511) protein (His tag)CSF1R 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Colony Stimulating Factor 1 Receptor (CSF1R) protein (His tag)CSF1R 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 538-972) (Active) protein (GST tag)CSF1R 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 543-972) (Active) protein (His-GST)CSF1R 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 99-596) protein (Fc Tag)CSF1R 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-512) protein (His tag)CSF1R 宿主: 人 宿主: HEK-293 Cells Recombinant >96 % as determined by SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))
- 别名
- CSF1R/CD115 (CSF1R 产品)
- 别名
- AI323359 Protein, CD115 Protein, CSF-1R Protein, Csfmr Protein, Fim-2 Protein, Fms Protein, M-CSF-R Protein, M-CSFR Protein, C-FMS Protein, CSFR Protein, FIM2 Protein, FMS Protein, HDLS Protein, PDGFRB Protein, MGC89146 Protein, CSF-1-R Protein, c-fms Protein, mrfms Protein, CSF1 Protein, M-CSF Protein, csf1r Protein, fms Protein, panther Protein, colony stimulating factor 1 receptor Protein, macrophage colony-stimulating factor receptor Protein, colony stimulating factor 1 receptor, a Protein, Csf1r Protein, CSF1R Protein, m-csfr Protein, csf1r Protein, csf1ra Protein
- 背景
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Background: M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein is consisted by an extracellular ligand-binding domain, a single membrane-spanning segment, and an intracellular tyrosine kinase domain. Binding of CSF1 activates the receptor kinase, leading to "autophosphorylation" of receptor subunits and the concomitant phosphorylation of a series of cellular proteins on tyrosine residues. CSF1R is a tyrosine kinase receptor that is absolutely required for macrophage differentiation and thus occupies a central role in hematopoiesis. CSF1 and its receptor (CSF1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. This apparent role for CSF1/CSF1R in normal mammary gland development is very intriguing because this receptor/ligand pair has also been found to be important in the biology of breast cancer in which abnormal expression of CSF1 and its receptor correlates with tumor cell invasiveness and adverse clinical prognosis. Tumor cell expression of CSF1R is under the control of several steroid hormones (glucocorticoids and progestins) and the binding of several bHLH transcription factors, while tumor cell expression of CSF-1 appears to be regulated by other hormones, some of which are involved in normal lactogenic differentiation. However, studies have demonstrated that CSF1 and CSF1R have additional roles in mammary gland development during pregnancy and lactation. The role of CSF1 and CSF1R in normal and neoplastic mammary development that may elucidate potential relationships of growth factor-induced biological changes in the breast during pregnancy and tumor progression.
Synonym: CSF1R;MCSF Receptor
- 分子量
- 82 kDa
- UniProt
- D4ACA7
- 途径
- RTK signaling, Inositol Metabolic Process, Cell-Cell Junction Organization
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