CSF1R Protein (AA 20-512) (Fc Tag)
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- 抗原 See all CSF1R 蛋白
- CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))
- 蛋白类型
- Recombinant
- 产品特性
- AA 20-512
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This CSF1R protein is labelled with Fc Tag.
- 原理
- Human M-CSF R/CSF1R/CD115 Protein
- 序列
- Ile20-Glu512
- 产品特性
- Recombinant Human M-CSF R/CSF1R/CD115 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Ile20-Glu512.
- 纯度
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- 过滤
- 0.22 μm filtered
- 内毒素水平
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human M-CSF at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Human M-CSF R, hFc Tag with the EC50 12.4ng/ml determined by ELISA. The affinity constant of 0.24 nM as determined in SPR assay (Biacore T200). See testing image for detail.
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Colony Stimulating Factor 1 Receptor (CSF1R) (AA 99-596) protein (His tag)
CSF1R 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Colony Stimulating Factor 1 Receptor (CSF1R) protein (His-Avi Tag,Biotin)CSF1R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-512) protein (His-Avi Tag)CSF1R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-511) protein (His tag)CSF1R 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Colony Stimulating Factor 1 Receptor (CSF1R) protein (His tag)CSF1R 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 538-972) (Active) protein (GST tag)CSF1R 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 543-972) (Active) protein (His-GST)CSF1R 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 99-596) protein (Fc Tag)CSF1R 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-512) protein (His tag)CSF1R 宿主: 人 宿主: HEK-293 Cells Recombinant >96 % as determined by SDS-PAGE.
Colony Stimulating Factor 1 Receptor (CSF1R) protein (Fc Tag)CSF1R 宿主: Cynomolgus 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- 缓冲液
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))
- 别名
- M-CSF R (CSF1R 产品)
- 别名
- AI323359 Protein, CD115 Protein, CSF-1R Protein, Csfmr Protein, Fim-2 Protein, Fms Protein, M-CSF-R Protein, M-CSFR Protein, C-FMS Protein, CSFR Protein, FIM2 Protein, FMS Protein, HDLS Protein, PDGFRB Protein, MGC89146 Protein, CSF-1-R Protein, c-fms Protein, mrfms Protein, CSF1 Protein, M-CSF Protein, csf1r Protein, fms Protein, panther Protein, colony stimulating factor 1 receptor Protein, macrophage colony-stimulating factor receptor Protein, colony stimulating factor 1 receptor, a Protein, Csf1r Protein, CSF1R Protein, m-csfr Protein, csf1r Protein, csf1ra Protein
- 背景
- CSF1R also known as M-CSF receptor, the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region.CSF1R is tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.
- 分子量
- 81.3 kDa. Due to glycosylation, the protein migrates to 100-130 kDa based on Tris-Bis PAGE result.
- 途径
- RTK signaling, Inositol Metabolic Process, Cell-Cell Junction Organization
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