CTNNB1 Protein (GST tag,His tag)
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- 抗原 See all CTNNB1 蛋白
- CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This CTNNB1 protein is labelled with GST tag,His tag.
- 原理
- Recombinant Human Beta-Catenin/CTNNB1 Protein (His & GST Tag)
- 序列
- Met 1-Leu 781
- 产品特性
- A DNA sequence encoding the human CTNNB1 (P35222-1) (Met 1-Leu 781) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 纯度
- > 85 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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- Discover our top product CTNNB1 蛋白
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Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 1-781) protein (GST tag)
CTNNB1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 682-781) protein (GST tag)CTNNB1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) protein (GST tag,His tag)CTNNB1 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 90 % as determined by SDS-PAGE
Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 2-781) protein (His tag)Crystallography grade CTNNB1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 2-781) protein (His tag)Crystallography grade CTNNB1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 2-781), (partial) protein (GST tag)CTNNB1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 95 % ELISA
Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) protein (DYKDDDDK Tag)CTNNB1 宿主: 人 宿主: Insect cells (Sf9) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 50 mM Tris, 100 mM NaCl, 2 mM GSH, 10 % glycerol, pH 8.0
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))
- 别名
- Beta-Catenin/CTNNB1 (CTNNB1 产品)
- 别名
- Jup Protein, LOC100217813 Protein, CTNNB1 Protein, CTNNB Protein, Bfc Protein, Catnb Protein, Mesc Protein, ctnnb Protein, id:ibd2058 Protein, wu:fb73e10 Protein, wu:fi81c06 Protein, wu:fk25h01 Protein, ctnnb1 Protein, CHBCAT Protein, MRD19 Protein, armadillo Protein, beta-catenin Protein, catenin beta 1 Protein, catenin (cadherin associated protein), beta 1 Protein, catenin (cadherin-associated protein), beta 1 Protein, catenin beta 1 S homeolog Protein, catenin beta 1 L homeolog Protein, CTNNB1 Protein, Ctnnb1 Protein, ctnnb1 Protein, ctnnb1.S Protein, ctnnb1.L Protein
- 背景
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Background: beta-Catenin, also known as CTNNB1, is a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain, which is specialized for protein-protein binding. It is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. CTNNB1 also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, beta-Catenin binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Defects in beta-Catenin can cause colorectal cancer, pilomatrixoma (PTR), medulloblastoma, and ovarian cancer. CTNNB1 is a key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, it forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, beta-Catenin is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. CTNNB1 is involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Synonym: armadillo,CTNNB,MRD19
- 分子量
- 113 kDa
- 途径
- WNT signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2
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