C-Type Lectin Domain Family 4, Member M (CLEC4M) protein (Fc Tag)
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- 抗原 See all C-Type Lectin Domain Family 4, Member M (CLEC4M) 蛋白
- C-Type Lectin Domain Family 4, Member M (CLEC4M)
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- Fc Tag
- 原理
- Recombinant Human DC-SIGNR/CD299/CLEC4M Protein (Fc Tag)
- 序列
- Ser 78-Glu 399
- 产品特性
- A DNA sequence encoding the extracellular domain (Ser 78-Glu 399) of human DC-SIGNR (NP_055072.3) was fused with the Fc region of human IgG1 at the N-terminus.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product CLEC4M 蛋白
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C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 285-394) protein (GST tag)
CLEC4M 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
C-Type Lectin Domain Family 4, Member M (CLEC4M) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)CLEC4M 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
C-Type Lectin Domain Family 4, Member M (CLEC4M) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)CLEC4M 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- C-Type Lectin Domain Family 4, Member M (CLEC4M)
- 别名
- DC-SIGNR/CD299/CLEC4M (CLEC4M 产品)
- 别名
- CD209L Protein, CD299 Protein, DC-SIGN2 Protein, DC-SIGNR Protein, DCSIGNR Protein, HP10347 Protein, L-SIGN Protein, LSIGN Protein, CD209B Protein, C-type lectin domain family 4 member M Protein, CLEC4M Protein
- 背景
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Background: C-type lectin domain family 4, member M, also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein that is 77 % amino acid identical to DC-SIGN, an HIV gp120-binding protein. Though the encoded gene located in the same chromosome, DC-SIGN is expressed solely on dendritic cells, while DC-SIGNR is predominantly found in liver sinusoidal endothelial cells and lymph node, as well as placental endothelium. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligermerization. DC-SIGNR is ragarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. DC-SIGNR appears to selectively recognize and bind many viral surface glycoproteins containing high mannose N-linked oligosaccharides in a calcium-dependent manner, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S, as well as the cellular adhesion protein ICAM3. DC-SIGNR have been thought to play an important role in establishing HIV infection by enhancing trans-infection of CD4(+)T cells in the regional lymph nodes. It may affect susceptibility to HIV infection by a mechanism that is different in females and males. DC-SIGNR can bind to hepatitis C virus (HCV), and its polymorphism might affect HCV loads supporting the concept that DC-SIGNR contributes to HCV replication efficacy.
Synonym: CD209L,CD299,CLEC4M,DC-SIGN2,DC-SIGNR,DCSIGNR,HP10347,L-SIGN,LSIGN,MGC129964,MGC47866
- 分子量
- 65 kDa
- NCBI登录号
- NP_055072
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