Claudin 18.2 (Active) protein (His tag,Twin-Strep tag)
宿主: 人
宿主: Insect Cells
Recombinant
>80 % as determined by SDS-PAGE.
Active
-
- 抗原
- Claudin 18.2
- 蛋白类型
- Recombinant
- 生物活性
- Active
-
宿主
- 人
-
资源
- Insect Cells
- 标记
- His tag,Twin-Strep tag
- 原理
- Human Claudin-18.2 Protein, His,Twin-Strep Tag (active membrane protein)
- 序列
- Met 1 - Ala 200
- 产品特性
- Human Claudin-18.2, His,Twin-Strep Tag (CL2-H5587) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Ala 200 (Accession # P56856-2).
- 纯度
- >80 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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Claudin 18.2 (AA 1-261) (Active) protein-VLP
宿主: 人 宿主: HEK-293 Cells VLP > 95 % as determined by HPLC ELISA, Func, Imm, SPR Active
Claudin 18.2 (AA 1-261) (Active) protein-VLP (Biotin)宿主: 人 宿主: HEK-293 Cells VLP > 95 % as determined by HPLC ELISA, Func, Imm, SPR Active
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- 应用备注
- This protein carries a polyhistidine tag at the N-terminus and a twin strep tag at the C-terminus. The protein has a calculated MW of 26.3 kDa. The protein migrates as 20 kDa and 40 kDa under non-reducing (NR) condition due to glycosylation.
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- 50 mM HEPES, 150 mM NaCl, DDM, CHS, pH 7.5
- 储存条件
- -80 °C
- 储存方法
- -70°C
-
- 抗原
- Claudin 18.2
- 别名
- Claudin-18.2
- 背景
-
Synonyms: Claudin-18.2,CLDN18,Claudin-18,
Description: Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells. - 分子量
- 26.3 kDa
- NCBI登录号
- NP_001002026
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