BEBOV GP Protein (AA 33-304) (His tag)
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- 抗原 See all BEBOV GP products
- BEBOV GP (Bundibugyo Ebola Virus Envelope Glycoprotein (BEBOV GP))
- 蛋白类型
- Recombinant
- 产品特性
- AA 33-304
- 宿主
- Ebola Virus
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资源
- HEK-293 Cells
- 标记
- This BEBOV GP protein is labelled with His tag.
- 原理
- Recombinant Ebolavirus (subtype Bundibugyo,strain Uganda 2007) Envelope Glycoprotein 1 (GP1) protein produced in HEK293 cells. Protein contains a C-terminal 6x His-tag
- 特异性
- Ebola virus envelope glycoprotein (GP1) is derived from the GP1 sequence (Accession # ACI28624), expressing Ile33 – Gln304.This Ebola virus envelope glycoprotein (GP1) is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 31.8 kDa. The protein is expressed in HEK293 cells.
- 产品特性
- Ebola Virus Envelope Glycoprotein (GP1) (Bundibugyo)
- 纯度
- >95 %
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Bundibugyo Ebola Virus Envelope Glycoprotein (BEBOV GP) protein (Fc Tag)
BEBOV GP 宿主: Ebola Virus 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE.
Bundibugyo Ebola Virus Envelope Glycoprotein (BEBOV GP) protein (His tag)BEBOV GP 宿主: Ebola Virus 宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by SDS-PAGE.
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- 说明
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This Ebola virus envelope glycoprotein (GP1) is derived from the GP1 sequence (Accession # ACI28624), expressing Ile33 – Gln304.This Ebola virus envelope glycoprotein (GP1) is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 31.8 kDa. The protein is expressed in HEK293 cells. DTT-reduced Protein migrates as 40-60 kDa in SDS-PAGE.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C
- 储存方法
- 4°C
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- 抗原
- BEBOV GP (Bundibugyo Ebola Virus Envelope Glycoprotein (BEBOV GP))
- 别名
- Ebola Envelope Glycoprotein (GP1) (Bundibugyo) (BEBOV GP 产品)
- 物质类
- Viral Protein
- 背景
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Ebola virus envelope glycoprotein is initially produced as a precursor known as pre-GP, which is cleaved by furin into two subunits, GP1 and GP2, which remain associated through a disulfide linkage between Cys53 of GP1 and Cys609 of GP2. This heterodimer assembles into a 450-kDa trimer at the surface of nascent virions. The virion-attached GP is critical in the EBOV life cycle, as it is solely responsible for attachment, fusion and entry of target cells. Moreover, GP is responsible for critical pathogenic differences among viral species.
Ebola hemorrhagic fever (EHF) is a severe disease caused by several species of Ebolavirus (EBOV), in the family Filoviridae. Prior to 2007, four species of EBOV had been identified, with two (Zaire ebolavirus andSudan ebolavirus) having caused significant disease outbreaks in humans. Outbreaks of EHF are associated with person-to-person transmission after the virus is introduced into humans from a zoonotic reservoir. During outbreaks the virus is commonly transmitted through direct contact with infected persons or their bodily fluids. The onset of EHF is associated with nonspecific signs and symptoms, including fever, myalgias, headache, abdominal pain, nausea, vomiting, and diarrhoea. In the later stages of disease, overt hemorrhage has been reported in up to 50% of cases.
The presence of a fifth EBOV virus species,Bundibugyo ebolavirus (BEBOV) was identified after an outbreak of EHF in the Bundibugyo District of western Uganda in 2007. - UniProt
- ACI28624
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