TRKA Protein (AA 33-417) (Fc Tag)
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- 抗原 See all TRKA (NTRK1) 蛋白
- TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 33-417
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This TRKA protein is labelled with Fc Tag.
- 纯度
- >95 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 0.1 EU per μg by the LAL method.
- Top Product
- Discover our top product NTRK1 蛋白
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Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 443-796) (Active) protein (His-GST)
NTRK1 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Active) protein (Fc Tag)NTRK1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Active) protein (His tag)NTRK1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Active) protein (His tag)NTRK1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Active) protein (Fc Tag)NTRK1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Tris with Glycine, Arginine and NaCl, pH 7.5
- 储存条件
- -20 °C
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- 抗原
- TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
- 别名
- TrkA (NTRK1 产品)
- 别名
- MTC Protein, TRK Protein, TRK1 Protein, TRKA Protein, Trk-A Protein, p140-TrkA Protein, CDHF12 Protein, CDHR16 Protein, HSCR1 Protein, MEN2A Protein, MEN2B Protein, MTC1 Protein, PTC Protein, RET-ELE1 Protein, RET51 Protein, Trk Protein, C80751 Protein, Tkr Protein, TrkA Protein, trk Protein, trka Protein, CTRKA Protein, trkA Protein, neurotrophic receptor tyrosine kinase 1 Protein, ret proto-oncogene Protein, neurotrophic tyrosine kinase, receptor, type 1 Protein, NTRK1 Protein, RET Protein, Ntrk1 Protein, ntrk1 Protein
- 背景
- Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.
- 分子量
- 68.2 kDa
- NCBI登录号
- NP_001012331
- 途径
- RTK signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process
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