CD68 Protein (AA 22-319) (Fc Tag)
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- 抗原 See all CD68 蛋白
- CD68 (CD68 Molecule (CD68))
- 蛋白类型
- Recombinant
- 产品特性
- AA 22-319
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宿主
- 人
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资源
- CHO Cells
- 标记
- This CD68 protein is labelled with Fc Tag.
- 原理
- CD68 (human):Fc (human) (rec.)
- 特异性
- The extracellular domain of human CD68 (aa 22-319) is fused to the N-terminus of the Fc region of human IgG1.
- 产品特性
- Protein. The extracellular domain of human CD68 (aa 22-319) is fused to the N-terminus of the Fc region of human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). CD68 is a single-pass type I membrane protein which belongs to the LAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocytes, fibroblasts and endothelial cells and in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. However, a number of studies have shown that CD68 antibodies react with other hematopoietic and non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen. CD68 binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
- 纯度
- >98 % (SDS-PAGE)
- 内毒素水平
- <0.06EU/μg protein (LAL test, Lonza).
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA assay.
- Top Product
- Discover our top product CD68 蛋白
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CD68 Molecule (CD68) (AA 164-262) protein (GST tag)
CD68 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
CD68 Molecule (CD68) protein (His tag)CD68 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
CD68 Molecule (CD68) protein (Fc Tag)CD68 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 浓度
- Lot specific
- 缓冲液
- Lyophilized from 0.2μm-filtered solution in PBS.
- 注意事项
- Avoid freeze/thaw cycles.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- 抗原
- CD68 (CD68 Molecule (CD68))
- 别名
- CD68 (CD68 产品)
- 别名
- Lamp4 Protein, Scard1 Protein, gp110 Protein, GP110 Protein, LAMP4 Protein, SCARD1 Protein, CD68 molecule Protein, CD68 antigen Protein, Cd68 molecule Protein, CD68 Protein, Cd68 Protein
- 背景
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Alternate Names/Synonyms: Macrosialin, GP110, Scavenger Receptor Class D Member 1, SCARD1
Product Description: CD68 is a single-pass type I membrane protein which belongs to the LAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocytes, fibroblasts and endothelial cells and in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. However, a number of studies have shown that CD68 antibodies react with other hematopoietic and non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen. CD68 binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
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