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CD68 Protein (His tag)

CD68 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
产品编号 ABIN7321138
发货至: 中国
  • 抗原 See all CD68 蛋白
    CD68 (CD68 Molecule (CD68))
    蛋白类型
    Recombinant
    宿主
    • 11
    • 5
    • 2
    大鼠
    资源
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    HEK-293 Cells
    标记
    This CD68 protein is labelled with His tag.
    原理
    Recombinant Rat CD68/Macrosialin Protein (His Tag)
    序列
    Met1-Ser295
    产品特性
    A DNA sequence encoding the rat CD68 (Q4FZY1) (Met1-Ser295) was expressed, fused with a polyhistidine tag at the C-terminus.
    纯度
    > 95 % as determined by SDS-PAGE
    内毒素水平
    < 1.0 EU per μg of the protein as determined by the LAL method
    Top Product
    Discover our top product CD68 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile PBS, pH 7.4
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    CD68 (CD68 Molecule (CD68))
    别名
    CD68/Macrosialin (CD68 产品)
    别名
    Lamp4 Protein, Scard1 Protein, gp110 Protein, GP110 Protein, LAMP4 Protein, SCARD1 Protein, CD68 molecule Protein, CD68 antigen Protein, Cd68 molecule Protein, CD68 Protein, Cd68 Protein
    背景

    Background: Macrosialin, also known as CD68 and Gp110, is a single-pass type I  membrane protein which belongs to the LAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocytes, fibroblasts and endothelial cells. CD68 is expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. However, a number of studies have shown that CD68 antibodies react with other hematopoietic and non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen. CD68 binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

    Synonym: CD68

    分子量
    30.9 kDa
    UniProt
    Q4FZY1
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