TIMD4 Protein (AA 22-279) (Fc Tag)
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- 抗原 See all TIMD4 蛋白
- TIMD4 (T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4))
- 蛋白类型
- Recombinant
- 产品特性
- AA 22-279
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宿主
- 小鼠
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资源
- CHO Cells
- 标记
- This TIMD4 protein is labelled with Fc Tag.
- 原理
- Tim-4 (mouse):Fc (human) (rec.)
- 特异性
- The extracellular domain of mouse Tim-4 (aa 22-279) is fused to the N-terminus of the Fc region of human IgG1.
- 产品特性
- Protein. The extracellular domain of mouse Tim-4 (aa 22-279) is fused to the N-terminus of the Fc region of human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). Mouse T cell immunoglobulin and mucin domain-containing protein 4, also known as T cell membrane protein 4, TIMD4 and TIM4 is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and TIM family. TIM4 contains one Ig-like V-type (immunoglobulin-like) domain. It is expressed on dendritic cells and macrophages. TIM4 plays an important role in the proliferation of T helper type 2 (Th2) cells. TIM4 is involved in regulating T cell proliferation and lymphotoxin signaling. It is a ligand for HAVCR1 / TIMD1. The expression of TIM4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIM4 and TIM1 are phosphatidylserine receptors for the engulfment of apoptotic cells and may also be involved in intercellular signaling in which exosomes are involved. Modulation of TIM4 production in dendritic cells (DCs) represents a novel therapeutic approach for the treatment of peanut allergy.
- 纯度
- >98 % (SDS-PAGE)
- 内毒素水平
- <0.06EU/μg protein (LAL test, Lonza).
- Biological Activity Comment
- Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
- Top Product
- Discover our top product TIMD4 蛋白
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T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 25-314) protein (His tag)
TIMD4 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 25-305) protein (His tag)TIMD4 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) protein (His tag)TIMD4 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 94 % as determined by SDS-PAGE
T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 25-314) protein (His tag)Crystallography grade TIMD4 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 23-279) protein (His tag)Crystallography grade TIMD4 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 25-378) protein (rho-1D4 tag)Crystallography grade TIMD4 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 23-343) protein (rho-1D4 tag)Crystallography grade TIMD4 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 浓度
- Lot specific
- 缓冲液
- Lyophilized from 0.2μm-filtered solution in PBS.
- 注意事项
- Avoid freeze/thaw cycles.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- 抗原
- TIMD4 (T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4))
- 别名
- Tim-4 (TIMD4 产品)
- 别名
- RGD1564516 Protein, MGC99322 Protein, TIMD4 Protein, B430010N18Rik Protein, TIM-4 Protein, Tim4 Protein, SMUCKLER Protein, TIM4 Protein, T-cell immunoglobulin and mucin domain containing 4 Protein, T-cell immunoglobulin and mucin domain containing 4 L homeolog Protein, T cell immunoglobulin and mucin domain containing 4 Protein, Timd4 Protein, TIMD4 Protein, timd4.L Protein
- 背景
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Alternate Names/Synonyms: TIM4, TIMD4, T Cell Immunoglobulin and Mucin Domain-containing Protein 4
Product Description: Mouse T cell immunoglobulin and mucin domain-containing protein 4, also known as T cell membrane protein 4, TIMD4 and TIM4 is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and TIM family. TIM4 contains one Ig-like V-type (immunoglobulin-like) domain. It is expressed on dendritic cells and macrophages. TIM4 plays an important role in the proliferation of T helper type 2 (Th2) cells. TIM4 is involved in regulating T cell proliferation and lymphotoxin signaling. It is a ligand for HAVCR1 / TIMD1. The expression of TIM4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIM4 and TIM1 are phosphatidylserine receptors for the engulfment of apoptotic cells and may also be involved in intercellular signaling in which exosomes are involved. Modulation of TIM4 production in dendritic cells (DCs) represents a novel therapeutic approach for the treatment of peanut allergy.
- NCBI登录号
- NP_848874
- 途径
- Cancer Immune Checkpoints
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